Literature summary for 1.13.11.34 extracted from

Roy, P.; Faye, D.; Blanchard, S.; Cormier, M.; Doiron, J.; Surette, M.; Touaibia, M.
New caffeic acid phenylethyl ester analogs bearing substituted triazole Synthesis and structure-activity relationship study towards 5-lipoxygenase inhibition (2017), J. Chem., 2017, 2380531 .

No PubMed abstract available

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in HEK-293 cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
(1-[2-[4-(trifluoromethyl)phenyl]ethyl]-1H-1,2,3-triazol-4-yl)methyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate	compound forms pi-pi interactions with residues Phe177, His367 and coordinates iron	Homo sapiens
[1-(2-cyclohexylethyl)-1H-1,2,3-triazol-4-yl]methyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate	compound is equipotent to zileuton. It forms pi-pi interactions with residues His367, Phe421 and coordinates iron	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P09917	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)