Literature summary for 1.13.11.34 extracted from

Doiron, J.A.; Leblanc, L.M.; Hebert, M.J.; Levesque, N.A.; Pare, A.F.; Jean-Francois, J.; Cormier, M.; Surette, M.E.; Touaibia, M.
Structure-activity relationship of caffeic acid phenethyl ester analogs as new 5-lipoxygenase inhibitors (2017), Chem. Biol. Drug Des., 89, 514-528 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
(2E)-3-[4-[(1E)-3-[[(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoyl]oxy]prop-1-en-1-yl]phenyl]prop-2-en-1-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate	caffeic acid phenylethyl ester analogue, IC50 value for inhibition of 5-Lox product synthesis in transfected HEK-293 cells is 0.00061 mM. Compound is a good radical scavenger	Homo sapiens
3-[4-(3-[[(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoyl]oxy]prop-1-yn-1-yl)phenyl]prop-2-yn-1-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate	caffeic acid phenylethyl ester analogue, IC50 value for inhibition of 5-Lox product synthesis in transfected HEK-293 cells is 0.00036 mM. Compound is a good radical scavenger	Homo sapiens
4-[(1E)-3-(3-phenylpropoxy)prop-1-en-1-yl]benzene-1,2-diol	caffeic acid phenylethyl ester analogue, IC50 value for inhibition of 5-Lox product synthesis in transfected HEK-293 cells is 0.00018 mM. Compound is a good radical scavenger	Homo sapiens
4-[(1E)-3-(benzyloxy)prop-1-en-1-yl]benzene-1,2-diol	caffeic acid phenylethyl ester analogue, IC50 value for inhibition of 5-Lox product synthesis in transfected HEK-293 cells is 0.00043 mM. Compound is a good radical scavenger	Homo sapiens
caffeic acid phenethyl ester	IC50 value for inhibition of 5-Lox product synthesis in transfected HEK-293 cells is 0.00099 mM. Compound is a good radical scavenger	Homo sapiens
zileuton	IC50 value for inhibition of 5-Lox product synthesis in transfected HEK-293 cells is 0.003 mM. Compound is a good radical scavenger	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P09917	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293 cell	-	Homo sapiens	-
leukocyte	polymorphonuclear leukocyte	Homo sapiens	-

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Release 2023.1 (January 2023)