Literature summary for 1.13.11.27 extracted from

Neuckermans, J.; Mertens, A.; De Win, D.; Schwaneberg, U.; De Kock, J.
A robust bacterial assay for high-throughput screening of human 4-hydroxyphenylpyruvate dioxygenase inhibitors (2019), Sci. Rep., 9, 14145 .

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Application

Application	Comment	Organism
analysis	colorimetric bacterial whole-cell screening system based on the degradation of tyrosine through 4-hydroxyphenylpyruvate into homogentisate by human HPD expressed in Escherichia coli and subsequent production of a soluble melanin-like pigment. The addition of prototypical beta-triketone HPD inhibitors decreases pigment production in a dose-dependent manner with increasing inhibitor concentrations. The high-throughput screening assay shows plate uniformity, signal variability and spatial uniformity assessment	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P32754	-	-

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Release 2023.1 (January 2023)