Literature summary for 1.11.1.23 extracted from

Zhou, S.; Pan, J.; Davis, K.M.; Schaperdoth, I.; Wang, B.; Boal, A.K.; Krebs, C.; Bollinger, J.M.
Steric enforcement of cis-epoxide formation in the radical C-O-coupling reaction by which (S)-2-hydroxypropylphosphonate epoxidase (HppE) produces fosfomycin (2019), J. Am. Chem. Soc., 141, 20397-20406 .

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Protein Variants

Protein Variants	Comment	Organism
F182A	the variant favors trans-fosfomycin production from (S)-2-hydroxypropylphosphonate	Streptomyces wedmorensis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(S)-2-hydroxypropylphosphonate + H2O2	Streptomyces wedmorensis	-	cis-fosfomycin + trans-fosfomycin + 2 H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Streptomyces wedmorensis	Q56185	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(S)-2-hydroxypropylphosphonate + H2O2	-	Streptomyces wedmorensis	cis-fosfomycin + trans-fosfomycin + 2 H2O	-	?

Synonyms

Synonyms	Comment	Organism
(S)-2-hydroxypropylphosphonate epoxidase	-	Streptomyces wedmorensis
HppE	-	Streptomyces wedmorensis

Cofactor

Cofactor	Comment	Organism	Structure
heme	-	Streptomyces wedmorensis

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Release 2023.1 (January 2023)