Crystallization (Comment) | Organism |
---|---|
- |
Mycobacterium tuberculosis |
hanging drop method, cocrystallization of 3-((methylsulfonyl)methyl)-2H-benzo[b][1,4]oxazin-2-one in complex with the enzyme | Staphylococcus aureus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
MMV553002 | i.e. 3-((methylsulfonyl)methyl)-2H-benzo[b][1,4]oxazin-2-one | Mycobacterium tuberculosis | |
MMV553002 | i.e. 3-((methylsulfonyl)methyl)-2H-benzo[b][1,4]oxazin-2-one | Staphylococcus aureus | |
MMV688271 | - |
Mycobacterium tuberculosis | |
MMV688271 | - |
Staphylococcus aureus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WKJ7 | - |
- |
Staphylococcus aureus | Q2FWK4 | - |
- |
Staphylococcus aureus NCTC 8325 | Q2FWK4 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
KARI | - |
Mycobacterium tuberculosis |
KARI | - |
Staphylococcus aureus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000222 | - |
MMV688271 | pH 8.0, temperature not specified in the publication | Staphylococcus aureus | |
0.0000384 | - |
MMV688271 | pH 8.0, temperature not specified in the publication | Mycobacterium tuberculosis | |
0.000153 | - |
MMV553002 | pH 8.0, temperature not specified in the publication | Mycobacterium tuberculosis | |
0.000531 | - |
MMV553002 | pH 8.0, temperature not specified in the publication | Staphylococcus aureus |
General Information | Comment | Organism |
---|---|---|
drug target | potential drug target for bacterial infections including Mycobacterium tuberculosis | Mycobacterium tuberculosis |
drug target | potential drug target for bacterial infections including Mycobacterium tuberculosis | Staphylococcus aureus |
metabolism | second enzyme in the branched-chain amino acid biosynthesis pathway | Mycobacterium tuberculosis |
metabolism | second enzyme in the branched-chain amino acid biosynthesis pathway | Staphylococcus aureus |