Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | P13491 | - |
- |
General Information | Comment | Organism |
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metabolism | LDH activity with free NADH and GAPDH-NADH complex always take place in parallel. NADH-channeling from D-glyceraldehyde-3-phosphate dehydrogenase (GAPDH) to L-lactate dehydrogenase (LDH) is observed only in assays that mimic cytosolic conditions where free NADH concentration is negligible and the GAPDH-NADH complex is dominant. LDH and GAPDH can form a leaky channeling complex only at the limiting NADH concentrations. A positive electric field between the NAD(H) binding sites on LDH and GAPDH tetramers can merge in the LDH-GAPDH complex | Oryctolagus cuniculus |