Application | Comment | Organism |
---|---|---|
drug development | a selective lactate dehydrogenase inhibitor targeting the L-malate dehydrogenase function of Plasmodium falciparum and its corresponding tricarboxylic acid cycle provides an attractive therapeutic opportunity, in contrast to LDH targeting due to the functional similarity between human and parasite LDHs | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Chloroquine | - |
Plasmodium falciparum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-lactate + NAD+ | Plasmodium falciparum | involved in glycolysis | pyruvate + NADH + H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-lactate + NAD+ | - |
Plasmodium falciparum | pyruvate + NADH + H+ | - |
r | |
(S)-lactate + NAD+ | involved in glycolysis | Plasmodium falciparum | pyruvate + NADH + H+ | - |
r | |
additional information | Plasmodium falciparum lactate dehydrogenase has L-malate dehydrogenase activity, which plays a role in the tricarboxylic acid cycle | Plasmodium falciparum | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LDH | - |
Plasmodium falciparum |