Application | Comment | Organism |
---|---|---|
synthesis | Papaver bracteatum hairy roots expressing CodR gene have a high potential to produce morphinan alkaloids | Papaver somniferum |
Cloned (Comment) | Organism |
---|---|
gene codR, expression in Papaver bracteatum in cultured hairy roots, subcloning in Escherichia coli strain DH5alpha. The T-DNA of the vector contains a neomycin phosphoteransferase gene and CodR cDNA with CaMV35S promoter and nos terminator | Papaver somniferum |
Protein Variants | Comment | Organism |
---|---|---|
additional information | transgenic codeinone reductase overexpressing Papaver somniferum plants show 75% increase in thebaine besides 58% and 22% increases in codeine and morphine, respectively, compared to the wild-type plants in the field trail | Papaver somniferum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
codeinone + NADPH + H+ | Papaver somniferum | - |
codeine + NADP+ | - |
r | |
additional information | Papaver somniferum | the enzyme also catalyzes the NADPH-dependent reduction of morphinone to morphine, reaction of EC 1.1.1.218. but codeine can also be directly converted into morphine, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Papaver somniferum | Q9SQ67 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leaf | - |
Papaver somniferum | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
codeinone + NADPH + H+ | - |
Papaver somniferum | codeine + NADP+ | - |
r | |
additional information | the enzyme also catalyzes the NADPH-dependent reduction of morphinone to morphine, reaction of EC 1.1.1.218. but codeine can also be directly converted into morphine, overview | Papaver somniferum | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
codeinone reductase (NADPH) | - |
Papaver somniferum |
CodR | - |
Papaver somniferum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Papaver somniferum | |
NADPH | - |
Papaver somniferum |