Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Al 1576 | - |
Canis lupus familiaris | |
Al 1576 | - |
Homo sapiens | |
Al 1576 | - |
Rattus norvegicus | |
ponalrestat | - |
Canis lupus familiaris | |
ponalrestat | - |
Homo sapiens | |
ponalrestat | - |
Rattus norvegicus | |
Tolrestat | - |
Canis lupus familiaris | |
Tolrestat | - |
Homo sapiens | |
Tolrestat | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.6 | - |
D-glucuronate | - |
Canis lupus familiaris | |
2.1 | - |
L-gulonate | - |
Canis lupus familiaris | |
3.1 | - |
D-glucuronate | - |
Homo sapiens | |
4.8 | - |
L-gulonate | - |
Homo sapiens | |
6.2 | - |
D-glucuronate | - |
Rattus norvegicus | |
7.6 | - |
L-gulonate | - |
Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
36000 | - |
gel filtration | Homo sapiens |
39000 | - |
gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucuronate + NADPH | Homo sapiens | - |
L-gulonate + NADP+ | - |
r | |
D-glucuronate + NADPH | Rattus norvegicus | - |
L-gulonate + NADP+ | - |
r | |
L-gulonate + NADP+ | Homo sapiens | - |
D-glucuronate + NADPH | - |
r | |
L-gulonate + NADP+ | Rattus norvegicus | - |
D-glucuronate + NADPH | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Canis lupus familiaris | - |
kidney | cortex | Homo sapiens | - |
kidney | cortex | Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
1.339 | - |
highly purified enzyme, substrate NADPH | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-aldose + NADPH | - |
Rattus norvegicus | L-alditol + NADP+ | - |
r | |
D-aldose + NADPH | i.e. D-xylose, D-glucose, D-galactose are reduced with 100fold less active than D-glucuronate | Homo sapiens | L-alditol + NADP+ | - |
r | |
D-glucuronate + NADPH | - |
Homo sapiens | L-gulonate + NADP+ | - |
r | |
D-glucuronate + NADPH | - |
Rattus norvegicus | L-gulonate + NADP+ | - |
r | |
D-glucuronate + NADPH + H+ | - |
Canis lupus familiaris | L-gulonate + NADP+ | - |
r | |
L-gulonate + NADP+ | - |
Homo sapiens | D-glucuronate + NADPH | - |
r | |
L-gulonate + NADP+ | - |
Rattus norvegicus | D-glucuronate + NADPH | - |
r | |
L-gulonate + NADP+ | - |
Canis lupus familiaris | D-glucuronate + NADPH + H+ | - |
r |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 39000, SDS-PAGE | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens | |
NADP+ | - |
Rattus norvegicus | |
NADP+ | - |
Canis lupus familiaris | |
NADPH | - |
Homo sapiens | |
NADPH | - |
Rattus norvegicus | |
NADPH | - |
Canis lupus familiaris |