Inhibitors | Comment | Organism | Structure |
---|---|---|---|
DL-3-hydroxybutyryl-CoA | competitive product inhibition | Streptococcus pneumoniae | |
NADP+ | competitive product inhibition | Streptococcus pneumoniae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | detailed steady-state kinetic analysis, solvent and multiple kinetic isotope effects, random bi bi kinetic mechanism | Streptococcus pneumoniae | |
0.4 | - |
NADPH | pH 7.6, 30°C | Streptococcus pneumoniae | |
2.2 | - |
acetoacetyl-CoA | pH 7.6, 30°C | Streptococcus pneumoniae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetoacetyl-CoA + NADPH | Streptococcus pneumoniae | - |
3-hydroxybutyryl-CoA + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus pneumoniae | - |
gene fabG | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = a 3-oxoacyl-[acyl-carrier protein] + NADPH + H+ | reaction mechanism, random bi bi kinetic mechanism | Streptococcus pneumoniae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetoacetyl-CoA + NADPH | - |
Streptococcus pneumoniae | 3-hydroxybutyryl-CoA + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
beta-ketoacyl-ACP reductase | - |
Streptococcus pneumoniae |
KACPR | - |
Streptococcus pneumoniae |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Streptococcus pneumoniae |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
11 | - |
NADPH | pH 7.6, 30°C | Streptococcus pneumoniae | |
11 | - |
acetoacetyl-CoA | pH 7.6, 30°C | Streptococcus pneumoniae |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.6 | - |
- |
Streptococcus pneumoniae |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5.5 | 9.5 | pH profile, detailed mechanistic pH-dependence analysis, overview | Streptococcus pneumoniae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Streptococcus pneumoniae |