Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Synonyms
extl2, alpha1,4-n-acetylglucosaminyltransferase, brother of tout-velu, exostosin-like 2, galntl-1, alpha-n-acetylglucosaminyltransferase i,
more
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
UDP-N-acetyl-D-galactosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-1-O-Ser
UDP + alpha-N-acetyl-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-1-O-Ser
UDP-N-acetyl-D-galactosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-O-naphthalenemethanol
UDP + alpha-N-acetyl-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl1-O-naphthalenemethanol
-
-
-
-
?
UDP-N-acetyl-D-galactosamine + beta-D-glucuronosyl-(1-3)-beta-D-N-acetylgalactosamine
UDP + alpha-N-acetyl-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-N-acetylgalactosamine
-
-
-
-
?
UDP-N-acetyl-D-glucosamine + alpha-thrombomodulin
UDP + alpha-N-acetyl-D-glucosaminyl-alpha-thrombomodulin
-
55% of the activity with beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-beta-O-C2H4NHCbz
-
-
?
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-1-beta-O-Ser-Gly-Trp-Pro-Asp-Gly
UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-1-beta-O-Ser-Gly-Trp-Pro-Asp-Gly
-
-
18% of the activity with beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-beta-O-C2H4NHCbz
-
?
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan
UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-beta-O-C2H4NHCbz
UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-beta-O-C2H4NHCbz
-
-
-
-
?
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-O-benzyloxycarbonyl
UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-O-benzyloxycarbonyl
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-O-naphthalenemethanol
UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl1-O-naphthalenemethanol
-
28% of the rate with UDP-N-acetyl-D-galactosamine
-
-
?
UDP-N-acetyl-D-glucosamine + glypican-1
UDP + alpha-N-acetyl-D-glucosaminyl-glypican-1
-
30% of the activity with beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-beta-O-C2H4NHCbz
-
-
?
additional information
?
-
UDP-N-acetyl-D-galactosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-1-O-Ser
UDP + alpha-N-acetyl-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-1-O-Ser
-
46% of the rate with beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-O-naphthalenemethanol
-
-
?
UDP-N-acetyl-D-galactosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-1-O-Ser
UDP + alpha-N-acetyl-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-1-O-Ser
-
-
-
?
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan
UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan
-
initiation and elongation of heparan sulfate
-
-
?
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan
UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan
-
-
-
?
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan
UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan
essential in the heparan sulfate biosynthesis
-
-
?
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan
UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan
-
-
-
-
?
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan
UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan
-
essential in the heparan sulfate biosynthesis
-
-
?
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-O-benzyloxycarbonyl
UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-O-benzyloxycarbonyl
-
-
-
-
?
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-O-benzyloxycarbonyl
UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-O-benzyloxycarbonyl
-
-
-
?
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-O-benzyloxycarbonyl
UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-O-benzyloxycarbonyl
-
-
-
-
?
additional information
?
-
-
activity is only detectable when enzymes are coexpressed, a mixture of individually expressed enzymes is inactive
-
-
?
additional information
?
-
-
no transfer of N-acetylglucosamine to beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-1-O-Ser
-
-
?
additional information
?
-
N-acetylgalactosaminyltransferase-like 1 specifically interferes with the activity of TGF-beta type II receptor ActR-IIB in vivo
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan
UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan
additional information
?
-
N-acetylgalactosaminyltransferase-like 1 specifically interferes with the activity of TGF-beta type II receptor ActR-IIB in vivo
-
-
?
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan
UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan
-
initiation and elongation of heparan sulfate
-
-
?
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan
UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan
essential in the heparan sulfate biosynthesis
-
-
?
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan
UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan
-
essential in the heparan sulfate biosynthesis
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Adenocarcinoma
A novel endo-beta-galactosidase from Clostridium perfringens that liberates the disaccharide GlcNAcalpha 1-->Gal from glycans specifically expressed in the gastric gland mucous cell-type mucin.
Carcinogenesis
Aberrant glycosaminoglycan biosynthesis by tumor suppressor EXTL2 deficiency promotes liver inflammation and tumorigenesis through Toll-like 4 receptor signaling.
Demyelinating Diseases
The glycosyltransferase EXTL2 promotes proteoglycan deposition and injurious neuroinflammation following demyelination.
Exostoses, Multiple Hereditary
Expression of rib-1, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes, is indispensable for heparan sulfate synthesis and embryonic morphogenesis.
Exostoses, Multiple Hereditary
rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate.
glucuronosyl-galactosyl-proteoglycan 4-alpha-n-acetylglucosaminyltransferase deficiency
Aberrant glycosaminoglycan biosynthesis by tumor suppressor EXTL2 deficiency promotes liver inflammation and tumorigenesis through Toll-like 4 receptor signaling.
Kashin-Beck Disease
Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease.
Mucopolysaccharidoses
Gene silencing of EXTL2 and EXTL3 as a substrate deprivation therapy for heparan sulphate storing mucopolysaccharidoses.
Mucopolysaccharidosis III
Gene silencing of EXTL2 and EXTL3 as a substrate deprivation therapy for heparan sulphate storing mucopolysaccharidoses.
Neoplasms
Aberrant glycosaminoglycan biosynthesis by tumor suppressor EXTL2 deficiency promotes liver inflammation and tumorigenesis through Toll-like 4 receptor signaling.
Neoplasms
Expression of rib-1, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes, is indispensable for heparan sulfate synthesis and embryonic morphogenesis.
Neoplasms
EXTL2, a Member of the EXT Family of Tumor Suppressors, Controls Glycosaminoglycan Biosynthesis in a Xylose Kinase-dependent Manner.
Neoplasms
rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate.
Neoplasms
Roles of EXTL2, a member of the EXT family of tumour suppressors, in liver injury and regeneration processes.
Neoplasms
The tumor suppressor EXT-like gene EXTL2 encodes an alpha1, 4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate.
Neuroinflammatory Diseases
The glycosyltransferase EXTL2 promotes proteoglycan deposition and injurious neuroinflammation following demyelination.
Osteoarthritis
Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease.
Pancreatic Neoplasms
Clinical utility of quantitative RT-PCR targeted to alpha1,4-N-acetylglucosaminyltransferase mRNA for detection of pancreatic cancer.
Stomach Neoplasms
Usefulness of the real-time reverse transcription-polymerase chain reaction assay targeted to alpha1,4-N-acetylglucosaminyltransferase for the detection of gastric cancer.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
EXT2_CAEEL
814
1
94197
Swiss-Prot
Secretory Pathway (Reliability: 2)
EXT3_DROME
972
1
111000
Swiss-Prot
other Location (Reliability: 3)
EXTL2_HUMAN
330
1
37466
Swiss-Prot
Secretory Pathway (Reliability: 1)
EXTL2_MOUSE
330
1
37391
Swiss-Prot
Secretory Pathway (Reliability: 1)
EXTL3_HUMAN
919
1
104749
Swiss-Prot
Mitochondrion (Reliability: 5)
EXTL3_MOUSE
918
1
104474
Swiss-Prot
Mitochondrion (Reliability: 5)
Q66KC7_XENTR
314
1
35429
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8M1N9R8_DANRE
332
1
38273
TrEMBL
Secretory Pathway (Reliability: 2)
A0A812EVH6_SEPPH
1269
14
149475
TrEMBL
Secretory Pathway (Reliability: 1)
A0A2P6PZU2_ROSCH
342
1
38628
TrEMBL
Secretory Pathway (Reliability: 2)
A0A2G9GBA6_9LAMI
255
0
29103
TrEMBL
Mitochondrion (Reliability: 5)
A0A6J8EBV2_MYTCO
304
0
34775
TrEMBL
other Location (Reliability: 4)
A0A7R8CVK3_LEPSM
244
0
28166
TrEMBL
other Location (Reliability: 2)
Q66JH0_XENTR
919
1
105249
TrEMBL
Mitochondrion (Reliability: 4)
A0A2I0BAS3_9ASPA
347
0
39012
TrEMBL
Chloroplast (Reliability: 3)
A0A6J8EC09_MYTCO
365
0
42803
TrEMBL
other Location (Reliability: 5)
A0A6J8C145_MYTCO
175
0
20632
TrEMBL
other Location (Reliability: 2)
A0A8B6EAE4_MYTGA
209
0
24454
TrEMBL
other Location (Reliability: 2)
A0A6J8C2D2_MYTCO
904
1
104617
TrEMBL
Secretory Pathway (Reliability: 1)
B9SCN4_RICCO
349
1
39464
TrEMBL
Secretory Pathway (Reliability: 5)
A0A812EML4_SEPPH
461
0
53845
TrEMBL
other Location (Reliability: 1)
A0A396JKC6_MEDTR
349
0
39465
TrEMBL
Chloroplast (Reliability: 5)
A0A0B2SVH6_GLYSO
332
1
38312
TrEMBL
Mitochondrion (Reliability: 1)
A0A2I0ANZ5_9ASPA
751
3
85752
TrEMBL
Mitochondrion (Reliability: 3)
A0A2I0ALB0_9ASPA
731
3
83369
TrEMBL
Secretory Pathway (Reliability: 1)
A0A6J8DBV2_MYTCO
859
1
98450
TrEMBL
Secretory Pathway (Reliability: 2)
A0A2I0AM32_9ASPA
324
1
35989
TrEMBL
Secretory Pathway (Reliability: 5)
Q5U7D2_DANRE
917
1
103853
TrEMBL
Secretory Pathway (Reliability: 4)
A0A0B2PRS9_GLYSO
352
1
39933
TrEMBL
other Location (Reliability: 1)
C0HAP2_SALSA
348
1
39155
TrEMBL
Secretory Pathway (Reliability: 2)
A0A6J8D557_MYTCO
489
0
56492
TrEMBL
Secretory Pathway (Reliability: 4)
A0A8B6G6I8_MYTGA
905
1
104259
TrEMBL
Secretory Pathway (Reliability: 2)
B9T3V5_RICCO
704
2
79493
TrEMBL
other Location (Reliability: 2)
Q6GQ89_XENLA
325
1
37227
TrEMBL
Secretory Pathway (Reliability: 1)
B9SLJ9_RICCO
329
1
37543
TrEMBL
Mitochondrion (Reliability: 1)
A0A6J8DDL9_MYTCO
905
1
104318
TrEMBL
Secretory Pathway (Reliability: 2)
Q6PA81_XENLA
559
0
64005
TrEMBL
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Kitagawa, H.; Egusa, N.; Tamura, J.I.; Kusche-Gullberg, M.; Lindahl, U.; Sugahara, K.
rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha-1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate
J. Biol. Chem.
276
4834-4838
2001
Caenorhabditis elegans
brenda
Kim, B.T.; Kitagawa, H.; Tamura, J.I.; Saito, T.; Kusche-Gullberg, M.; Lindahl, U.; Sugahara, K.
Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha-1,4-N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/heparin biosynthesis
Proc. Natl. Acad. Sci. USA
98
7176-7181
2001
Homo sapiens
brenda
Kim, B.T.; Kitagawa, H.; Tamura, J.I.; Kusche-Gullberg, M.; Lindahl, U.; Sugahara, K.
Demonstration of a novel gene DEXT3 of Drosophila melanogaster as the essential N-acetylglucosamine transferase in the heparan sulfate biosynthesis: Chain initiation and elongation
J. Biol. Chem.
277
13659-13665
2002
Drosophila melanogaster (Q9XZ08)
brenda
Han, C.; Belenkaya, T.Y.; Khodoun, M.; Tauchi, M.; Lin, X.; Lin, X.
Distinct and collaborative roles of Drosophila EXT family proteins in morphopgen signalling and gradient formation
Development
131
1563-1575
2005
Drosophila melanogaster
brenda
Kitagawa, H.; Shimakawa, H.; Sugahara, K.
The tumor suppressor EXT-like gene EXTL2 encodes an alpha1,4N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glucosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate
J. Biol. Chem.
274
13933-13937
1999
Homo sapiens
brenda
Kim, B.T.; Kitagawa, H.; Tanaka, J.; Tamura, J.I.; Sugahara, K.
In vitro heparan sulfate polymerization: crucial roles of core protein moieties of primer substrates in addition to the EXT1-EXT2 interaction
J. Biol. Chem.
278
41618-41623
2003
Homo sapiens
brenda
Herr, P.; Korniychuk, G.; Yamamoto, Y.; Grubisic, K.; Oelgeschlaeger, M.
Regulation of TGF-beta signalling by N-acetylgalactosaminyltransferase-like 1
Development
135
1813-1822
2008
Xenopus laevis (Q6PA81)
brenda
Awad, W.; Kjellstroem, S.; Svensson Birkedal, G.; Mani, K.; Logan, D.T.
Structural and biophysical characterization of human EXTL3 domain organization, glycosylation, and solution structure
Biochemistry
57
1166-1177
2018
Homo sapiens (O43909)
brenda
Nadanaka, S.; Kitagawa, H.
Exostosin-like 2 regulates FGF2 signaling by controlling the endocytosis of FGF2
Biochim. Biophys. Acta Gen. Subj.
1862
791-799
2018
Mus musculus (Q9ES89), Mus musculus
brenda
Sembajwe, L.; Katta, K.; Gronning, M.; Kusche-Gullberg, M.
The exostosin family of glycosyltransferases MRNA expression profiles and heparan sulphate structure in human breast carcinoma cell lines
Biosci. Rep.
38
1-12
2018
Homo sapiens (O43909), Homo sapiens (Q9UBQ6), Homo sapiens
brenda