Disease on EC 2.4.1.22 - lactose synthase
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Adenocarcinoma
Aberrant promoter methylation of beta-1,4 galactosyltransferase 1 as potential cancer-specific biomarker of colorectal tumors.
Adenocarcinoma
Galactosyltransferase B4GALT1 confers chemoresistance in pancreatic ductal adenocarcinomas by upregulating N-linked glycosylation of CDK11p110.
Adenocarcinoma of Lung
Proteomic analysis of lung adenocarcinoma: identification of a highly expressed set of proteins in tumors.
Adenoma
Aberrant promoter methylation of beta-1,4 galactosyltransferase 1 as potential cancer-specific biomarker of colorectal tumors.
Adenoma, Pleomorphic
Cell-surface galactosyltransferase acts as a modulator of rat and human acinar cell proliferation.
Alopecia
Anti-alopecia effect of Gly-Leu-Phe, an immunostimulating peptide derived from alpha-lactalbumin.
Anaphylaxis
Goats' milk of defective alpha(s1)-casein genotype decreases intestinal and systemic sensitization to beta-lactoglobulin in guinea pigs.
Anaphylaxis
Pasteurization of milk proteins promotes allergic sensitization by enhancing uptake through Peyer's patches.
Anaphylaxis
Successful management of severe cow's milk allergy with omalizumab treatment and CD-sens monitoring.
Anemia
Effects of micronised dispersible ferric pyrophosphate combined with alpha-lactalbumin in pregnant women affected by iron deficiency anemia: results from a prospective, double-blind, randomized controlled trial.
Anemia, Iron-Deficiency
Effects of micronised dispersible ferric pyrophosphate combined with alpha-lactalbumin in pregnant women affected by iron deficiency anemia: results from a prospective, double-blind, randomized controlled trial.
Argininosuccinic Aciduria
Impaired development of mammary glands in scorbutic rats unable to synthesize ascorbic acid.
Arthritis, Rheumatoid
Agalactosyl IgG and beta-1,4-galactosyltransferase gene expression in rheumatoid arthritis patients and in the arthritis-prone MRL lpr/lpr mouse.
Asthma, Occupational
Occupational asthma and rhinoconjunctivitis from inhalation of dried cow's milk caused by sensitization to alpha-lactalbumin.
Asymptomatic Infections
Gene expression of factors related to the immune reaction in response to intramammary Escherichia coli lipopolysaccharide challenge.
Autoimmune Diseases
Human Retrotransposon Insertion Polymorphisms Are Associated with Health and Disease via Gene Regulatory Phenotypes.
Breast Cyst
Presence of alpha-lactalbumin, epidermal growth factor, epithelial membrane antigen, and gross cystic disease fluid protein (15,000 daltons) in breast cyst fluid.
Breast Diseases
alpha-Lactalbumin levels in human mammary tumors, sera, and mammary cell culture lines.
Breast Neoplasms
Adenovirus-mediated tissue-targeted expression of the HSVtk gene for the treatment of breast cancer.
Breast Neoplasms
Alpha-lactalbumin and GCDFP-15 as breast tumor markers (an opportunity to study breast tumors functionally).
Breast Neoplasms
Alpha-lactalbumin as an immunohistochemical marker for metastatic breast carcinomas.
Breast Neoplasms
alpha-Lactalbumin in human and subhuman primate normal mammary tissue and in human breast cancer as a marker for prolactin activity.
Breast Neoplasms
alpha-Lactalbumin is not a marker of human hormone-dependent breast cancer.
Breast Neoplasms
alpha-Lactalbumin levels in human mammary tumors, sera, and mammary cell culture lines.
Breast Neoplasms
An autoimmune-mediated strategy for prophylactic breast cancer vaccination.
Breast Neoplasms
Breast cancer vaccines delivered by dendritic cell-targeted lentivectors induce potent antitumor immune responses and protect mice from mammary tumor growth.
Breast Neoplasms
Casein and alpha-lactalbumin detection in breast cancer cells by immunocytochemistry.
Breast Neoplasms
Comprehensive N-glycome profiling of cultured human epithelial breast cells identifies unique secretome N-glycosylation signatures enabling tumorigenic subtype classification.
Breast Neoplasms
Conversion of the amphiphilic galactosyltransferase from human mammary carcinoma cells to an active hydrophilic enzyme form by limited proteolysis.
Breast Neoplasms
Detection of alpha-lactalbumin in breast lesions and relationship to estrogen receptors and serum prolactin.
Breast Neoplasms
Discrimination by RT-Nested PCR of Alpha-Lactalbumin Transcript Expression in Mammary Tumors.
Breast Neoplasms
Gross cystic disease fluid protein-15 as a marker for breast cancer: immunohistochemical analysis of 690 human neoplasms and comparison with alpha-lactalbumin.
Breast Neoplasms
Human alpha-lactalbumin: measurement in serum and in breast cancer organ cultures by radioimmunoassay.
Breast Neoplasms
Immunohistochemical localization of alpha-lactalbumin in human breast cancer tissue.
Breast Neoplasms
Molecular cloning of a human cDNA encoding beta-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc beta-1,4-galactosyltransferase.
Breast Neoplasms
Opposite effects of estrogen and catecholestrogen on hormone-sensitive breast cancer cell growth and differentiation.
Breast Neoplasms
Production and characterization of murine monoclonal antibody to human alpha-lactalbumin.
Breast Neoplasms
Prognostic significance of immunohistochemical parameters in breast carcinomas.
Breast Neoplasms
Studies on human alpha-lactalbumin: radioimmunoassay measurements in normal human breast and breast cancer.
Breast Neoplasms
Transcriptional targeting modalities in breast cancer gene therapy using adenovirus vectors controlled by alpha-lactalbumin promoter.
Breast Neoplasms
[Immunohistochemistry of alpha-lactalbumin, lactoferrin and trans- ferrin receptor in invasive breast carcinomas with regard to tumor grading, estrogen receptor status and tumor staging]
Carcinoma
alpha-Lactalbumin content of rat mammary carcinomas and the effect of pituitary stimulation.
Carcinoma
Alpha-lactalbumin in "common" epithelial tumors of the ovary. An immunohistochemical study.
Carcinoma
alpha-Lactalbumin levels in human mammary tumors, sera, and mammary cell culture lines.
Carcinoma
Alteration in the metastatic potential of ovarian cancer cells by transfection of the antisense gene of beta-1,4-galactosyltransferase.
Carcinoma
An enzyme-linked immunosorbent assay for lactose synthase (galactosyltransferase) in serum and its application as a tumor marker in ovarian carcinoma.
Carcinoma
Beta-1,4-galactosyltransferase II predicts poor prognosis of patients with non-metastatic clear-cell renal cell carcinoma.
Carcinoma
Breast carcinoma in patients receiving neuroleptic therapy. Morphologic and clinicopathologic features of thirteen cases.
Carcinoma
Conversion of the amphiphilic galactosyltransferase from human mammary carcinoma cells to an active hydrophilic enzyme form by limited proteolysis.
Carcinoma
Detection of alpha-lactalbumin in breast lesions and relationship to estrogen receptors and serum prolactin.
Carcinoma
Eccrine sweat gland carcinoma: an histologic and immunohistochemical study of 32 cases.
Carcinoma
Endogenous oligonucleotides of human milk and their possible biological function.
Carcinoma
Increased B4GALT1 expression associates with adverse outcome in patients with non-metastatic clear cell renal cell carcinoma.
Carcinoma
N-Glycosylation of total cellular glycoproteins from the human ovarian carcinoma SKOV3 cell line and of recombinantly expressed human erythropoietin.
Carcinoma
Primary adenoid cystic carcinoma of the skin. A clinical, histological, and immunocytochemical comparison with adenoid cystic carcinoma of salivary glands and adenoid basal cell carcinoma.
Carcinoma
Priming mass spectrometry-based sulfoglycomic mapping for identification of terminal sulfated lacdiNAc glycotope.
Carcinoma
Secretory carcinoma coexistent with mucinous carcinoma in the breast. Report of a case.
Carcinoma
Secretory carcinoma of the breast: light microscopical, immunohistochemical and flow cytometric study.
Carcinoma
Studies on human alpha-lactalbumin: radioimmunoassay measurements in normal human breast and breast cancer.
Carcinoma
Ultrastructural and immunohistochemical characteristics of lipid-rich carcinoma of the breast.
Carcinoma, Adenoid Cystic
Primary adenoid cystic carcinoma of the skin. A clinical, histological, and immunocytochemical comparison with adenoid cystic carcinoma of salivary glands and adenoid basal cell carcinoma.
Carcinoma, Ductal
Detection of alpha-lactalbumin in breast lesions and relationship to estrogen receptors and serum prolactin.
Carcinoma, Embryonal
Cell surface and Golgi pools of beta-1,4-galactosyltransferase are differentially regulated during embryonal carcinoma cell differentiation.
Carcinoma, Embryonal
Molecular cloning and characterization of beta-1,4-galactosyltransferase expressed in mouse testis.
Carcinoma, Embryonal
Uvomorulin, LAMP-1, and laminin are substrates for cell surface beta-1,4-galactosyltransferase on F9 embryonal carcinoma cells: comparisons between wild-type and mutant 5.51 att- cells.
Carcinoma, Hepatocellular
Effect of all-trans-retinoic acid and phorbol 12-myristate 13-acetate on the activity of human hepatocellular carcinoma cell-surface beta-1,4-galactosyltransferase.
Carcinoma, Hepatocellular
Interactions of cell-surface galactosyltransferase with immunoglobulins.
Carcinoma, Hepatocellular
The chicken genome contains two functional nonallelic beta1,4-galactosyltransferase genes. Chromosomal assignment to syntenic regions tracks fate of the two gene lineages in the human genome.
Carcinoma, Intraductal, Noninfiltrating
Ductal Carcinoma In Situ Progression in Dog Model of Breast Cancer.
Carcinoma, Ovarian Epithelial
Correlation of UDP-galactose glycoprotein:galactosyltransferase levels in the sera with the clinical status of ovarian cancer patients.
Carcinoma, Renal Cell
Beta-1,4-galactosyltransferase II predicts poor prognosis of patients with non-metastatic clear-cell renal cell carcinoma.
Carcinoma, Renal Cell
Increased B4GALT1 expression associates with adverse outcome in patients with non-metastatic clear cell renal cell carcinoma.
Celiac Disease
Gut permeability to human alpha-lactalbumin, beta-lactoglobulin, mannitol, and lactulose in celiac disease.
Celiac Disease
Influence of cow's milk proteins and gluten on human duodenal mucosa in organ culture.
Cholera
Cyclic AMP as a negative regulator of hormonally induced lactogenesis in mouse mammary gland organ culture.
Cholera
Pituitary-induced lactation in mammary gland explants from the pregnant tammar (Macropus eugenii): a negative role for cyclic AMP.
Choriocarcinoma
Unusually high expression of N-acetylglucosaminyltransferase-IVa in human choriocarcinoma cell lines: a possible enzymatic basis of the formation of abnormal biantennary sugar chain.
Colitis, Ulcerative
Serum antibodies to cow's milk proteins in pediatric inflammatory bowel disease: Crohn's disease vs. ulcerative colitis.
Colitis, Ulcerative
Serum antibodies to cow's milk proteins in ulcerative colitis and Crohn's disease.
Colitis, Ulcerative
The effect of proctocolectomy on serum antibody levels against cow's milk proteins in patients with chronic ulcerative colitis, with special reference to liver changes.
Colonic Neoplasms
Growth rates of a human colon adenocarcinoma cell line are regulated by the milk protein alpha-lactalbumin.
Colorectal Neoplasms
?1, 4-N-acetylgalactosaminyltransferase III modulates cancer stemness through EGFR signaling pathway in colon cancer cells.
Colorectal Neoplasms
Aberrant promoter methylation of beta-1,4 galactosyltransferase 1 as potential cancer-specific biomarker of colorectal tumors.
Colorectal Neoplasms
Diagnostic and Prognostic Value of B4GALT1 Hypermethylation and Its Clinical Significance as a Novel Circulating Cell-Free DNA Biomarker in Colorectal Cancer.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
B4GALT1-congenital disorders of glycosylation: Expansion of the phenotypic and molecular spectrum and review of the literature.
Crohn Disease
Human Retrotransposon Insertion Polymorphisms Are Associated with Health and Disease via Gene Regulatory Phenotypes.
Crohn Disease
Serum antibodies to cow's milk proteins in pediatric inflammatory bowel disease: Crohn's disease vs. ulcerative colitis.
Crohn Disease
Serum antibodies to cow's milk proteins in ulcerative colitis and Crohn's disease.
Cystadenoma
A combined blood based gene expression and plasma protein abundance signature for diagnosis of epithelial ovarian cancer--a study of the OVCAD consortium.
Cysts
Presence of alpha-lactalbumin, epidermal growth factor, epithelial membrane antigen, and gross cystic disease fluid protein (15,000 daltons) in breast cyst fluid.
Dementia, Vascular
Construction of a ceRNA immunoregulatory network related to the development of vascular dementia through a weighted gene coexpression network analysis.
Dermatitis, Atopic
Occurrence and subclass distribution of IgG antibodies to dietary antigens in children with atopic dermatitis and in their mothers.
Dermatitis, Atopic
Specific humoral response to cows' milk proteins and ovalbumin in children with atopic dermatitis.
Diabetes Mellitus, Type 1
Circulating antibodies to common food antigens in Japanese children with IDDM.
Diabetes Mellitus, Type 2
Experts' opinion on inositols in treating polycystic ovary syndrome and non-insulin dependent diabetes mellitus: a further help for human reproduction and beyond.
Endometrial Neoplasms
Changes of beta-1,4-galactosyltransferase with the development of endometrial cancer.
Endometriosis
Differentially expressed gene profiles in the serum before and after the ultrasound-guided ethanol sclerotherapy in patients with ovarian endometriomas.
Galactorrhea
Composition of breast fluid of a man with galactorrhea and hyperprolactinaemia.
Glaucoma, Open-Angle
Identification of Mutations in Myocilin and Beta-1,4-galactosyltransferase 3 Genes in a Chinese Family with Primary Open-angle Glaucoma.
Glioblastoma
B4GalT1 Regulates Apoptosis and Autophagy of Glioblastoma In Vitro and In Vivo.
Glioblastoma
Human alpha-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival.
Glomerulonephritis, IGA
Development of immunoglobulin A nephropathy- like disease in beta-1,4-galactosyltransferase-I-deficient mice.
Glomerulonephritis, Membranoproliferative
Mucosal immunity in primary glomerulonephritis: II. Study of the serum IgA subclass repertoire to food and airborne antigens.
Granuloma
LacdiNAc- and LacNAc-containing glycans induce granulomas in an in vivo model for schistosome egg-induced hepatic granuloma formation.
Gynecomastia
Studies on human alpha-lactalbumin: radioimmunoassay measurements in normal human breast and breast cancer.
Hepatitis B
Mechanism of adsorption of three recombinant Streptococcus pneumoniae (Sp) vaccine antigens by an aluminum adjuvant.
Herpes Simplex
Antiviral activity of esterified alpha-lactalbumin and beta-lactoglobulin against herpes simplex virus type 1. Comparison with the effect of acyclovir and L-polylysines.
Herpes Zoster
A role for mouse sperm surface galactosyltransferase in sperm binding to the egg zona pellucida.
Herpes Zoster
Aggregation of beta-1,4-galactosyltransferase on mouse sperm induces the acrosome reaction.
Herpes Zoster
Beta-1,4-galactosyltransferase expression during spermatogenesis: stage-specific regulation by t alleles and uniform distribution in + -spermatids and t-spermatids.
Herpes Zoster
Can relative spermatozoal galactosyltransferase activity be predictive of dairy bull fertility?
Herpes Zoster
Distribution and dynamics of mouse sperm surface galactosyltransferase: implications for mammalian fertilization.
Herpes Zoster
Effects of bovine mammary alpha-lactalbumin on hyperactivation and sperm-zona pellucida binding of mouse spermatozoa.
Herpes Zoster
Relationship between two types of mouse sperm surface sites that mediate binding of sperm to the zona pellucida.
Herpes Zoster
Sperm from a variety of mammalian species express beta1,4-galactosyltransferase on their surface.
Hyperprolactinemia
Composition of breast fluid of a man with galactorrhea and hyperprolactinaemia.
Hypersensitivity
A hydrolysed rice-based formula is tolerated by children with cow's milk allergy: a multi-centre study.
Hypersensitivity
Allergy to the heat-labile proteins alpha-lactalbumin and beta-lactoglobulin in mare's milk.
Hypersensitivity
B-cell epitopes as a screening instrument for persistent cow's milk allergy.
Hypersensitivity
Human IgE binding capacity of tryptic peptides from bovine alpha-lactalbumin.
Hypersensitivity
Immune reactivity of cow-asthmatic dairy farmers to the major allergen of cow (BDA20) and to other cow-derived proteins. The use of purified BDA20 increases the performance of diagnostic tests in respiratory cow allergy.
Hypopituitarism
Targeted mutation in beta1,4-galactosyltransferase leads to pituitary insufficiency and neonatal lethality.
Infections
Effect of bovine somatotropin on neutrophil functions and clinical symptoms during Streptococcus uberis mastitis.
Infections
LacdiNAc- and LacNAc-containing glycans induce granulomas in an in vivo model for schistosome egg-induced hepatic granuloma formation.
Infections
Mammalian glycosyltransferase expression allows sialoglycoprotein production by baculovirus-infected insect cells.
Infections
Novel baculovirus expression vectors that provide sialylation of recombinant glycoproteins in lepidopteran insect cells.
Infections
Physiological and pathological factors influencing bovine alpha-lactalbumin and beta-lactoglobulin concentrations in milk.
Infections
Proteomic analysis of the temporal expression of bovine milk proteins during coliform mastitis and label-free relative quantification.
Inflammatory Bowel Diseases
Serum antibodies to cow's milk proteins in pediatric inflammatory bowel disease: Crohn's disease vs. ulcerative colitis.
lactose synthase deficiency
Lactation is disrupted by alpha-lactalbumin deficiency and can be restored by human alpha-lactalbumin gene replacement in mice.
Leukemia
B4GALT family mediates the multidrug resistance of human leukemia cells by regulating the hedgehog pathway and the expression of p-glycoprotein and multidrug resistance-associated protein 1.
Leukemia
B4GALT1 gene knockdown inhibits the hedgehog pathway and reverses multidrug resistance in the human leukemia K562/adriamycin-resistant cell line.
Leukemia
LacdiNAc (GalNAc?1-4GlcNAc) Contributes to Self-Renewal of Mouse Embryonic Stem Cells by Regulating Leukemia Inhibitory Factor/STAT3 Signaling.
Leukemia
Measurement of beta-galactosyltransferase activity in cell extracts with an ELISA-based assay.
Leukemia
Molecular basis for recognition of the cancer glycobiomarker LacdiNAc (GalNAc(?1-4)GlcNAc) by Wisteria floribunda agglutinin.
Leukemia, Myeloid, Acute
[Effect of B4GALT1 on Proliferation of Its Co-cultured Human Acute Myeloid Leukemia Cell Line in Bone Marrow Stromal Cells].
Liver Diseases
Increased serum antibody levels against cow's milk proteins in children with chronic liver disease.
Liver Neoplasms
Molecular basis for recognition of the cancer glycobiomarker LacdiNAc (GalNAc(?1-4)GlcNAc) by Wisteria floribunda agglutinin.
Lung Neoplasms
B4GALT1 Is a New Candidate to Maintain the Stemness of Lung Cancer Stem Cells.
Lung Neoplasms
Isolation and characterization of cancer-associated galactosyltransferase isoenzyme.
Lupus Erythematosus, Systemic
Human Retrotransposon Insertion Polymorphisms Are Associated with Health and Disease via Gene Regulatory Phenotypes.
Lymphatic Metastasis
alpha-Lactalbumin levels in human mammary tumors, sera, and mammary cell culture lines.
Lymphatic Metastasis
Galactosyltransferase B4GALT1 confers chemoresistance in pancreatic ductal adenocarcinomas by upregulating N-linked glycosylation of CDK11p110.
Lymphoma
Human ovarian cancer, lymphoma spleen, and bovine milk GlcNAc:beta1,4Gal/GalNAc transferases: two molecular species in ovarian tumor and induction of GalNAcbeta1,4Glc synthesis by alpha-lactalbumin.
Lymphoma
Inhibition of lactogenic activities of ovine prolactin and human growth hormone (hGH) by a novel form of a modified recombinant hGH.
Mastitis
Changes in lactoferrin, immunoglobulin G, bovine serum albumin, and alpha-lactalbumin during acute experimental and natural coliform mastitis in cows.
Mastitis
Pathology of Staphylococcus aureus mastitis during lactogenesis: relationships with bovine mammary structure and function.
Mastitis
Protein composition of whey from subclinical mastitis and effect of treatment with levamisole.
Melanoma
Functionally distinct laminin receptors mediate cell adhesion and spreading: the requirement for surface galactosyltransferase in cell spreading.
Milk Hypersensitivity
Allergy to the heat-labile proteins alpha-lactalbumin and beta-lactoglobulin in mare's milk.
Milk Hypersensitivity
B-cell epitopes as a screening instrument for persistent cow's milk allergy.
Milk Hypersensitivity
Effect of extensively hydrolyzed milk formula on growth and resistance to bronchitis and atopic dermatitis in infants and toddlers.
Milk Hypersensitivity
Human IgE binding capacity of tryptic peptides from bovine alpha-lactalbumin.
Milk Hypersensitivity
IgE and IgG binding epitopes on alpha-lactalbumin and beta-lactoglobulin in cow's milk allergy.
Milk Hypersensitivity
Pasteurization of milk proteins promotes allergic sensitization by enhancing uptake through Peyer's patches.
Milk Hypersensitivity
Successful management of severe cow's milk allergy with omalizumab treatment and CD-sens monitoring.
Milk Hypersensitivity
[Specific IgE antibodies to cow's milk and individual cow's milk proteins in children with suspected allergy to cow's milk]
Myalgia
Effects of Alpha-Lactalbumin or Whey Protein Isolate on Muscle Damage, Muscle Pain, and Mood States Following Prolonged Strenuous Endurance Exercise.
Myalgia
The effect of carbohydrate and protein co-ingestion on energy substrate metabolism, sense of effort, and affective responses during prolonged strenuous endurance exercise.
Myocardial Infarction
Expression profiles of long noncoding RNAs and messenger RNAs in the border zone of myocardial infarction in rats.
Neoplasm Metastasis
alpha-Lactalbumin levels in human mammary tumors, sera, and mammary cell culture lines.
Neoplasm Metastasis
B4GALT1 expression predicts prognosis and adjuvant chemotherapy benefits in muscle-invasive bladder cancer patients.
Neoplasm Metastasis
Diagnostic and Prognostic Value of B4GALT1 Hypermethylation and Its Clinical Significance as a Novel Circulating Cell-Free DNA Biomarker in Colorectal Cancer.
Neoplasm Metastasis
Galactosyltransferase B4GALT1 confers chemoresistance in pancreatic ductal adenocarcinomas by upregulating N-linked glycosylation of CDK11p110.
Neoplasm Metastasis
Identification of a novel glycolysis-related gene signature for predicting metastasis and survival in patients with lung adenocarcinoma.
Neoplasms
A combined blood based gene expression and plasma protein abundance signature for diagnosis of epithelial ovarian cancer--a study of the OVCAD consortium.
Neoplasms
A folding variant of human alpha-lactalbumin induces mitochondrial permeability transition in isolated mitochondria.
Neoplasms
A non-competitive enzyme immunoassay of human alpha-lactalbumin in biological fluids and tissue extracts.
Neoplasms
Aberrant promoter methylation of beta-1,4 galactosyltransferase 1 as potential cancer-specific biomarker of colorectal tumors.
Neoplasms
alpha-Lactalbumin binding and membrane integrity--effect of charge and degree of unsaturation of glycerophospholipids.
Neoplasms
Alpha-lactalbumin in "common" epithelial tumors of the ovary. An immunohistochemical study.
Neoplasms
alpha-Lactalbumin levels in human mammary tumors, sera, and mammary cell culture lines.
Neoplasms
Alpha-lactalbumin unfolding is not sufficient to cause apoptosis, but is required for the conversion to HAMLET (human alpha-lactalbumin made lethal to tumor cells).
Neoplasms
alpha-Lactalbumin, Engineered to be Nonnative and Inactive, Kills Tumor Cells when in Complex with Oleic Acid: A New Biological Function Resulting from Partial Unfolding.
Neoplasms
Alteration in the metastatic potential of ovarian cancer cells by transfection of the antisense gene of beta-1,4-galactosyltransferase.
Neoplasms
An enzyme-linked immunosorbent assay for lactose synthase (galactosyltransferase) in serum and its application as a tumor marker in ovarian carcinoma.
Neoplasms
Apoptosis and tumor cell death in response to HAMLET (human alpha-lactalbumin made lethal to tumor cells).
Neoplasms
Apoptosis-Like Death in Bacteria Induced by HAMLET, a Human Milk Lipid-Protein Complex.
Neoplasms
Apoptotic cell death in the lactating mammary gland is enhanced by a folding variant of alpha-lactalbumin.
Neoplasms
Augmenting the cytotoxicity of oleic acid-protein complexes: Potential of target-specific antibodies.
Neoplasms
B4GALT1 expression predicts prognosis and adjuvant chemotherapy benefits in muscle-invasive bladder cancer patients.
Neoplasms
Behaviour of oleic acid-depleted bovine alpha-lactalbumin made LEthal to tumor cells (BAMLET).
Neoplasms
Beta-1,4-galactosyltransferase II predicts poor prognosis of patients with non-metastatic clear-cell renal cell carcinoma.
Neoplasms
Beta-sheet-specific interactions with heat shock proteins define a mechanism of delayed tumor cell death in response to HAMLET.
Neoplasms
Bladder cancer therapy using a conformationally fluid tumoricidal peptide complex.
Neoplasms
Bladder cancers respond to intravesical instillation of HAMLET (human alpha-lactalbumin made lethal to tumor cells).
Neoplasms
Casein and alpha-lactalbumin detection in breast cancer cells by immunocytochemistry.
Neoplasms
Characterization and immunoassay of human tumor-associated galactosyltransferase isoenzyme II.
Neoplasms
Conformational analysis of HAMLET, the folding variant of human alpha-lactalbumin associated with apoptosis.
Neoplasms
Conversion of human alpha-lactalbumin to an apo-like state in the complexes with basic poly-amino acids: toward understanding of the molecular mechanism of antitumor action of HAMLET.
Neoplasms
Correlation of UDP-galactose glycoprotein:galactosyltransferase levels in the sera with the clinical status of ovarian cancer patients.
Neoplasms
Cytotoxic aggregates of alpha-lactalbumin induced by unsaturated fatty acid induce apoptosis in tumor cells.
Neoplasms
Detection of alpha-lactalbumin in breast lesions and relationship to estrogen receptors and serum prolactin.
Neoplasms
Discrimination by RT-Nested PCR of Alpha-Lactalbumin Transcript Expression in Mammary Tumors.
Neoplasms
Eccrine sweat gland carcinoma: an histologic and immunohistochemical study of 32 cases.
Neoplasms
Effect of denaturation of alpha-lactalbumin on the formation of BAMLET (bovine alpha-lactalbumin made lethal to tumor cells).
Neoplasms
Effect of estradiol and prolactin on galactosyltransferase and alpha-lactalbumin activities in rat mammary gland and mammary tumor.
Neoplasms
Effects of hormones on growth and alpha-lactalbumin activity in the transplantable rat mammary tumor MCCLX.
Neoplasms
Efficient and specific ribozyme-mediated reduction of bovine alpha-lactalbumin expression in double transgenic mice.
Neoplasms
Enhanced expression of the ?4-N-acetylgalactosaminyltransferase 4 gene impairs tumor growth of human breast cancer cells.
Neoplasms
Galactosyltransferase associated with tumor in patients with ovarian cancer: factors involved in elevation of serum galactosyltransferase.
Neoplasms
Galactosyltransferase B4GALT1 confers chemoresistance in pancreatic ductal adenocarcinomas by upregulating N-linked glycosylation of CDK11p110.
Neoplasms
Glycogen-rich clear cell carcinoma of the breast: a solid variant with mucus. A light microscopic, immunohistochemical and ultrastructural study of a case.
Neoplasms
Gross cystic disease fluid protein-15 as a marker for breast cancer: immunohistochemical analysis of 690 human neoplasms and comparison with alpha-lactalbumin.
Neoplasms
Growth rates of a human colon adenocarcinoma cell line are regulated by the milk protein alpha-lactalbumin.
Neoplasms
HAMLET (human alpha-lactalbumin made lethal to tumor cells) triggers autophagic tumor cell death.
Neoplasms
HAMLET interacts with lipid membranes and perturbs their structure and integrity.
Neoplasms
HAMLET kills tumor cells by an apoptosis-like mechanism--cellular, molecular, and therapeutic aspects.
Neoplasms
HAMLET kills tumor cells by apoptosis: structure, cellular mechanisms, and therapy.
Neoplasms
HAMLET triggers apoptosis but tumor cell death is independent of caspases, Bcl-2 and p53.
Neoplasms
Heat-treatment method for producing fatty acid-bound alpha-lactalbumin that induces tumor cell death.
Neoplasms
High affinity oestradiol receptors and the activity of glucose-6-phosphate dehydrogenase and lactose synthetase in mammary carcinomata of postmenopausal women.
Neoplasms
Human alpha-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival.
Neoplasms
Human alpha-lactalbumin: measurement in serum and in breast cancer organ cultures by radioimmunoassay.
Neoplasms
Human ovarian cancer, lymphoma spleen, and bovine milk GlcNAc:beta1,4Gal/GalNAc transferases: two molecular species in ovarian tumor and induction of GalNAcbeta1,4Glc synthesis by alpha-lactalbumin.
Neoplasms
Immunohistochemical localization of alpha-lactalbumin in human breast cancer tissue.
Neoplasms
Increased B4GALT1 expression associates with adverse outcome in patients with non-metastatic clear cell renal cell carcinoma.
Neoplasms
Interaction of antitumor alpha-lactalbumin-oleic acid complexes with artificial and natural membranes.
Neoplasms
Isoenzymatic patterns of human galactosyltransferase from normal and cancer patients.
Neoplasms
Lipids as cofactors in protein folding: stereo-specific lipid-protein interactions are required to form HAMLET (human alpha-lactalbumin made lethal to tumor cells).
Neoplasms
Low resolution solution structure of HAMLET and the importance of its alpha-domains in tumoricidal activity.
Neoplasms
Measurement of alpha-lactalbumin in serum and mammary tumors of rats by radioimmunoassay.
Neoplasms
Molecular basis for recognition of the cancer glycobiomarker LacdiNAc (GalNAc(?1-4)GlcNAc) by Wisteria floribunda agglutinin.
Neoplasms
Molecular characterization of alpha-lactalbumin folding variants that induce apoptosis in tumor cells.
Neoplasms
Multifaceted roles of 5'-regulatory region of the cancer associated gene B4GALT1 and its comparison with the gene family.
Neoplasms
Multimeric alpha-lactalbumin from human milk induces apoptosis through a direct effect on cell nuclei.
Neoplasms
No need to be HAMLET or BAMLET to interact with histones: binding of monomeric alpha-lactalbumin to histones and basic poly-amino acids.
Neoplasms
Oleic acid complex of bovine ?-lactalbumin induces eryptosis in human and other erythrocytes by a Ca(2+)-independent mechanism.
Neoplasms
POFUT1 mRNA expression as an independent prognostic parameter in muscle-invasive bladder cancer.
Neoplasms
Protein oligomerization induced by oleic acid at the solid-liquid interface--equine lysozyme cytotoxic complexes.
Neoplasms
Protein receptor-independent plasma membrane remodeling by HAMLET: a tumoricidal protein-lipid complex.
Neoplasms
Protein-coding capacities of polyadenylated RNAs from normal and neoplastic rat mammary tissues.
Neoplasms
Sample handling of gastric tissue and O-glycan alterations in paired gastric cancer and non-tumorigenic tissues.
Neoplasms
Secretory carcinoma of the breast: light microscopical, immunohistochemical and flow cytometric study.
Neoplasms
Sensitization of Staphylococcus aureus to methicillin and other antibiotics in vitro and in vivo in the presence of HAMLET.
Neoplasms
Separation and characterization of the neoplastic and stromal elements of the R3230AC mammary adenocarcinoma.
Neoplasms
Sequential action of Ets-1 and Sp1 in the activation of the human beta-1,4-galactosyltransferase V gene involved in abnormal glycosylation characteristic of cancer cells.
Neoplasms
Small-angle X-ray scattering of BAMLET at pH 12: A complex of ?-lactalbumin and oleic acid.
Neoplasms
Structural Insights into the Molecular Recognition Mechanism of the Cancer and Pathogenic Epitope, LacdiNAc by Immune-Related Lectins.
Neoplasms
Studies on human alpha-lactalbumin: radioimmunoassay measurements in normal human breast and breast cancer.
Neoplasms
Targeting of nucleotide-binding proteins by HAMLET-a conserved tumor cell death mechanism.
Neoplasms
The AKR1C3/AR-V7 complex maintains CRPC tumour growth by repressing B4GALT1 expression.
Neoplasms
The effect of mouse mammary tumor virus receptor activation on mammary epithelial cell sensitivity toward prolactin.
Neoplasms
The interaction of equine lysozyme:oleic acid complexes with lipid membranes suggests a cargo off-loading mechanism.
Neoplasms
The Molecular Motor F-ATP Synthase Is Targeted by the Tumoricidal Protein HAMLET.
Neoplasms
The oleic acid complexes of proteolytic fragments of alpha-lactalbumin display apoptotic activity.
Neoplasms
The relationship between the branch-forming glycosyltransferases and cell surface sugar chain structures.
Neoplasms
The toxicity of BAMLET is highly dependent on oleic acid and induces killing in cancer cell lines and non-cancer derived primary cells.
Neoplasms
Transcriptional regulation of the human beta-1,4-galactosyltransferase V gene in cancer cells: essential role of transcription factor Sp1.
Neoplasms
Transcriptional targeting modalities in breast cancer gene therapy using adenovirus vectors controlled by alpha-lactalbumin promoter.
Neoplasms
Use and relevance of a bovine mammary gland explant model to study infection responses in bovine mammary tissue.
Neoplasms
Who is Mr. HAMLET? Interaction of human alpha-lactalbumin with monomeric oleic acid.
Neoplasms
Wisteria floribunda Agglutinin and Its Reactive-Glycan-Carrying Prostate-Specific Antigen as a Novel Diagnostic and Prognostic Marker of Prostate Cancer.
Neoplasms
[Immunohistochemistry of alpha-lactalbumin, lactoferrin and trans- ferrin receptor in invasive breast carcinomas with regard to tumor grading, estrogen receptor status and tumor staging]
Neoplasms
[Quantitative immunoenzyme determination of the lactoferrin and alpha-lactalbumin in the blood serum of cancer patients]
Neoplasms
[Value and prognostic significance of alpha-lactalbumin (ALA), lactoferrin (Lfr) and HMFG-2 in primary breast cancers. An immunohistochemical study]
Ovarian Neoplasms
Alteration in isoenzyme patterns of serum galactosyltransferase activity in ovarian cancer patients: preliminary results.
Ovarian Neoplasms
Alteration in the metastatic potential of ovarian cancer cells by transfection of the antisense gene of beta-1,4-galactosyltransferase.
Ovarian Neoplasms
Evaluation of beta1,4-galactosyltransferase as a potential biomarker for the detection of subclinical disease after the completion of primary therapy for ovarian cancer.
Ovarian Neoplasms
Human ovarian cancer, lymphoma spleen, and bovine milk GlcNAc:beta1,4Gal/GalNAc transferases: two molecular species in ovarian tumor and induction of GalNAcbeta1,4Glc synthesis by alpha-lactalbumin.
Paget's Disease, Mammary
Alpha-lactalbumin as an immunohistochemical marker for metastatic breast carcinomas.
Pancreatic Neoplasms
Expression of LacdiNAc groups on N-glycans among human tumors is complex.
Pleural Effusion
alpha-Lactalbumin levels in human mammary tumors, sera, and mammary cell culture lines.
Pleural Effusion
Isolation and characterization of cancer-associated galactosyltransferase isoenzyme.
Prostatic Neoplasms
Detection of N,N-diacetyllactosamine (LacdiNAc) containing free prostate-specific antigen for early stage prostate cancer diagnostics and for identification of castration-resistant prostate cancer patients.
Prostatic Neoplasms
Identification of Multisialylated LacdiNAc Structures as Highly Prostate Cancer Specific Glycan Signatures on PSA.
Prostatic Neoplasms
Wisteria floribunda Agglutinin and Its Reactive-Glycan-Carrying Prostate-Specific Antigen as a Novel Diagnostic and Prognostic Marker of Prostate Cancer.
Prostatitis
Detection of N,N-diacetyllactosamine (LacdiNAc) containing free prostate-specific antigen for early stage prostate cancer diagnostics and for identification of castration-resistant prostate cancer patients.
Retinoblastoma
Comparative gene mapping of lactoperoxidase, retinoblastoma, and alpha-lactalbumin genes in cattle, sheep, and goats.
Rickets, Hypophosphatemic
Hypersensitivity reaction in an infant fed hydrolyzed lactalbumin contained in a semielemental formula.
Rotavirus Infections
Antirotaviral activity of milk proteins: lactoferrin prevents rotavirus infection in the enterocyte-like cell line HT-29.
Sarcoma
Sheep gene mapping: additional DNA markers included (CASB, CASK, LALBA, IGF-1 and AMH).
Starvation
Nutritional regulation of milk protein messenger RNA concentrations in mammary acini isolated from lactating rats.
Urinary Bladder Neoplasms
B4GALT1 expression predicts prognosis and adjuvant chemotherapy benefits in muscle-invasive bladder cancer patients.
Urinary Bladder Neoplasms
Bladder cancers respond to intravesical instillation of HAMLET (human alpha-lactalbumin made lethal to tumor cells).
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