Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2 S-adenosyl-L-methionine + aloe emodin
2 S-adenosyl-L-homocysteine + O-methylaloe emodin
-
-
-
?
2 S-adenosyl-L-methionine + beta-sitosterol
2 S-adenosyl-L-homocysteine + O-methyl-beta-sitosterol
-
-
-
?
2 S-adenosyl-L-methionine + daunorubicin
2 S-adenosyl-L-homocysteine + O-methyldaunorubicin
-
-
-
?
2 S-adenosyl-L-methionine + emodin
2 S-adenosyl-L-homocysteine + O-methylemodin
-
-
-
?
2 S-adenosyl-L-methionine + genistein
2 S-adenosyl-L-homocysteine + O-methylgenistein + O,O'-dimethylgenistein + O,O',O''-trimethylgenistein
-
-
-
?
2 S-adenosyl-L-methionine + kaempferol
2 S-adenosyl-L-homocysteine + 3,7-O-dimethylkaempferol
-
activity only of enzyme mutant POMT7-M1, D257G, not of wild-type POMT7
-
-
?
2 S-adenosyl-L-methionine + luteolin
2 S-adenosyl-L-homocysteine + methoxyluteolin
-
-
-
?
2 S-adenosyl-L-methionine + phloretin
2 S-adenosyl-L-homocysteine + methoxyphloretin
-
-
-
?
2 S-adenosyl-L-methionine + quercetin
2 S-adenosyl-L-homocysteine + 3,7-O-dimethylquercetin
-
activity only of enzyme mutant POMT7-M1, D257G, not of wild-type POMT7, molecular docking of quercetin into the modeled structure of Asp257Gly
-
-
?
S-adenosyl-L-methionine + (2S)-5,7,4'-trihydroxyflavanone
S-adenosyl-L-homocysteine + (2S)-5,4'-dihydroxy-7-methoxyflavanone
S-adenosyl-L-methionine + (2S)-naringenin
S-adenosyl-L-homocysteine + (2S)-sakuranetin
S-adenosyl-L-methionine + 3,3',4',5,7-pentahydroxyflavone
S-adenosyl-L-homocysteine + 3,3',4',5-tetrahydroxy-7-methoxyflavone
S-adenosyl-L-methionine + 3,4',5,7-tetrahydroxyflavanone
S-adenosyl-L-homocysteine + 3,4',5-trihydroxy-7-methoxyflavanone
-
i.e. kaempferol, active is identical to that with (2S)-naringenin (i.e. (2S)-5,7,4'-trihydroxyflavanone)
-
-
?
S-adenosyl-L-methionine + 3,5,7,4'-tetrahydroxy-3'-methoxyflavone
S-adenosyl-L-homocysteine + 3,5,4'-trihydroxy-7,3'-dimethoxyflavone
S-adenosyl-L-methionine + 3-hydroxyflavone
S-adenosyl-L-homocysteine + 3-methoxyflavone
-
-
-
?
S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone
S-adenosyl-L-homocysteine + 5,4'-dihydroxy-7-methoxyflavone
S-adenosyl-L-methionine + 5,7,4'-trihydroxyisoflavone
S-adenosyl-L-homocysteine + 5,4'-dihydroxy-7-methoxyisoflavone
-
i.e. genistein. 59% of the activity with (2S)-naringenin (i.e. (2S)-5,7,4'-trihydroxyflavanone)
-
-
?
S-adenosyl-L-methionine + 7,4'-dihydroxyisoflavone
S-adenosyl-L-homocysteine + 4'-hydroxy-7-methoxyisoflavone
S-adenosyl-L-methionine + 7,8-dihydroxyflavone
S-adenosyl-L-homocysteine + 7-hydroxy-8-methoxyflavone
-
-
-
?
S-adenosyl-L-methionine + apigenin
S-adenosyl-L-homocysteine + genkwanin + 5-hydroxy-7,4'-dimethoxyflavone
S-adenosyl-L-methionine + dihydrokaempferol
S-adenosyl-L-homocysteine + 7-O-methylaromadendrin
S-adenosyl-L-methionine + kaempferol
S-adenosyl-L-homocysteine + 7-O-methylkaempferol
-
-
-
-
?
S-adenosyl-L-methionine + naringenin
S-adenosyl-L-homocysteine + sakuranetin + 5-hydroxy-7,4'-dimethoxyflavanone + 4'-hydroxy-5,7-dimethoxyflavanone
S-adenosyl-L-methionine + quercetin
S-adenosyl-L-homocysteine + 7-O-methylquercetin
-
-
-
-
?
S-adenosyl-L-methionine + resveratrol
S-adenosyl-L-homocysteine + desoxyrhapontigenin + 5-hydroxy-3,4'-dimethoxystilbene
S-adenosyl-L-methionine + (2S)-5,7,4'-trihydroxyflavanone
S-adenosyl-L-homocysteine + (2S)-5,4'-dihydroxy-7-methoxyflavanone
-
i.e. (2S)-naringenin
i.e. (2S)-sakuranetin
-
?
S-adenosyl-L-methionine + (2S)-5,7,4'-trihydroxyflavanone
S-adenosyl-L-homocysteine + (2S)-5,4'-dihydroxy-7-methoxyflavanone
-
i.e. (2S)-naringenin
i.e. (2S)-sakuranetin
-
?
S-adenosyl-L-methionine + (2S)-naringenin
S-adenosyl-L-homocysteine + (2S)-sakuranetin
-
-
-
?
S-adenosyl-L-methionine + (2S)-naringenin
S-adenosyl-L-homocysteine + (2S)-sakuranetin
-
-
-
-
?
S-adenosyl-L-methionine + 3,3',4',5,7-pentahydroxyflavone
S-adenosyl-L-homocysteine + 3,3',4',5-tetrahydroxy-7-methoxyflavone
-
i.e. quercetin, 119% of the activity with (2S)-naringenin (i.e. (2S)-5,7,4'-trihydroxyflavanone)
-
-
?
S-adenosyl-L-methionine + 3,3',4',5,7-pentahydroxyflavone
S-adenosyl-L-homocysteine + 3,3',4',5-tetrahydroxy-7-methoxyflavone
-
i.e. quercetin, 119% of the activity with (2S)-naringenin (i.e. (2S)-5,7,4'-trihydroxyflavanone)
-
-
?
S-adenosyl-L-methionine + 3,5,7,4'-tetrahydroxy-3'-methoxyflavone
S-adenosyl-L-homocysteine + 3,5,4'-trihydroxy-7,3'-dimethoxyflavone
-
i.e. isorhamnetin, 57% of the activity with (2S)-naringenin (i.e. (2S)-5,7,4'-trihydroxyflavanone)
-
-
?
S-adenosyl-L-methionine + 3,5,7,4'-tetrahydroxy-3'-methoxyflavone
S-adenosyl-L-homocysteine + 3,5,4'-trihydroxy-7,3'-dimethoxyflavone
-
i.e. isorhamnetin, 57% of the activity with (2S)-naringenin (i.e. (2S)-5,7,4'-trihydroxyflavanone)
-
-
?
S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone
S-adenosyl-L-homocysteine + 5,4'-dihydroxy-7-methoxyflavone
-
i.e. apigenin, 23.4% of the activity with (2S)-naringenin (i.e. (2S)-5,7,4'-trihydroxyflavanone)
i.e. genkwanin
-
?
S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone
S-adenosyl-L-homocysteine + 5,4'-dihydroxy-7-methoxyflavone
-
i.e. apigenin, 23.4% of the activity with (2S)-naringenin (i.e. (2S)-5,7,4'-trihydroxyflavanone)
i.e. genkwanin
-
?
S-adenosyl-L-methionine + 7,4'-dihydroxyisoflavone
S-adenosyl-L-homocysteine + 4'-hydroxy-7-methoxyisoflavone
-
i.e. daidzein. 126% of the activity with (2S)-naringenin (i.e. (2S)-5,7,4'-trihydroxyflavanone)
i.e. formononetin
-
?
S-adenosyl-L-methionine + 7,4'-dihydroxyisoflavone
S-adenosyl-L-homocysteine + 4'-hydroxy-7-methoxyisoflavone
-
i.e. daidzein. 126% of the activity with (2S)-naringenin (i.e. (2S)-5,7,4'-trihydroxyflavanone)
i.e. formononetin
-
?
S-adenosyl-L-methionine + apigenin
S-adenosyl-L-homocysteine + genkwanin + 5-hydroxy-7,4'-dimethoxyflavone
-
-
-
?
S-adenosyl-L-methionine + apigenin
S-adenosyl-L-homocysteine + genkwanin + 5-hydroxy-7,4'-dimethoxyflavone
-
-
-
?
S-adenosyl-L-methionine + dihydrokaempferol
S-adenosyl-L-homocysteine + 7-O-methylaromadendrin
-
i.e. 7-O-methyl-dihydrokaempferol
-
?
S-adenosyl-L-methionine + dihydrokaempferol
S-adenosyl-L-homocysteine + 7-O-methylaromadendrin
-
-
i.e. 7-O-methyl-dihydrokaempferol
-
?
S-adenosyl-L-methionine + naringenin
S-adenosyl-L-homocysteine + sakuranetin + 5-hydroxy-7,4'-dimethoxyflavanone + 4'-hydroxy-5,7-dimethoxyflavanone
-
-
-
?
S-adenosyl-L-methionine + naringenin
S-adenosyl-L-homocysteine + sakuranetin + 5-hydroxy-7,4'-dimethoxyflavanone + 4'-hydroxy-5,7-dimethoxyflavanone
-
-
-
?
S-adenosyl-L-methionine + resveratrol
S-adenosyl-L-homocysteine + desoxyrhapontigenin + 5-hydroxy-3,4'-dimethoxystilbene
-
-
-
?
S-adenosyl-L-methionine + resveratrol
S-adenosyl-L-homocysteine + desoxyrhapontigenin + 5-hydroxy-3,4'-dimethoxystilbene
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Kim, B.G.; Jung, B.R.; Lee, Y.; Hur, H.G.; Lim, Y.; Ahn, J.H.
Regiospecific flavonoid 7-O-methylation with Streptomyces avermitilis O-methyltransferase expressed in Escherichia coli
J. Agric. Food Chem.
54
823-828
2006
Streptomyces avermitilis, Streptomyces avermitilis MA-4680
brenda
Joe, E.J.; Kim, B.G.; An, B.C.; Chong, Y.; Ahn, J.H.
Engineering of flavonoid O-methyltransferase for a novel regioselectivity
Mol. Cells
30
137-141
2010
Populus sp.
brenda
Malla, S.; Koffas, M.A.; Kazlauskas, R.J.; Kim, B.G.
Production of 7-O-methyl aromadendrin, a medicinally valuable flavonoid, in Escherichia coli
Appl. Environ. Microbiol.
78
684-694
2012
Streptomyces avermitilis (Q79ZE8)
brenda
Parajuli, P.; Pandey, R.P.; Nguyen, T.H.T.; Dhakal, D.; Sohng, J.K.
Substrate scope of O-methyltransferase from Streptomyces peucetius for biosynthesis of diverse natural products methoxides
Appl. Biochem. Biotechnol.
184
1404-1420
2018
Streptomyces peucetius subsp. caesius (A0A1B1W6Z7), Streptomyces peucetius subsp. caesius ATCC 27952 (A0A1B1W6Z7)
brenda
Cui, H.; Song, M.; Ban, Y.; Jun, S.; Kwon, A.; Lee, J.; Yoon, Y.
High-yield production of multiple O-methylated phenylpropanoids by the engineered Escherichia coli-Streptomyces cocultivation system
Microb. Cell Fact.
18
67
2019
Streptomyces avermitilis (Q79ZE8), Streptomyces avermitilis DSM 46492 (Q79ZE8)
brenda