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Information on EC 2.1.1.226 - 23S rRNA (cytidine1920-2'-O)-methyltransferase

for references in articles please use BRENDA:EC2.1.1.226
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EC Tree
IUBMB Comments
The bifunctional enzyme from Mycobacterium tuberculosis 2'-O-methylates cytidine1920 in helix 69 of 23S rRNA and cytidine1409 in helix 44 of 16S rRNA (cf. EC 2.1.1.227, 16S rRNA (cytidine1409-2'-O)-methyltransferase). These methylations result in increased susceptibility to the antibiotics capreomycin and viomycin.
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Word Map
  • 2.1.1.226
  • aminoglycosides
  • amikacin
  • carbapenemase
  • extended-spectrum
  • plasmid-mediated
  • esbls
  • carbapenem-resistant
  • aminoglycoside-modifying
  • methylase-producing
  • blactx-m
  • aac6\'-ib
  • aac6\'-ib-cr
  • blatem
  • blactx-m-15
  • aminoglycoside-resistant
  • arbekacin
  • blakpc-2
  • macrolide-lincosamide-streptogramin
  • ndm-1-producing
  • carbapenemase-producing
  • amikacin-resistant
  • carbapenemase-encoding
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
Synonyms
rrna methylase, cj0588, tlyaii, rrna 2'-o-methyltransferase, rrna methylase tlya, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + cytidine1920 in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
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