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The enzyme appears in viruses and cellular organisms
Synonyms
n-methylalanine dehydrogenase,
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N-methyl-L-alanine + H2O + NADP+ = pyruvate + methylamine + NADPH + H+
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N-methyl-L-alanine:NADP+ oxidoreductase (demethylating, deaminating)
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methylamine + alpha-ketobutyrate + NADPH
glutamic acid + H2O + NADP+
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14% of activity with pyruvate
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methylamine + oxaloacetate + NADPH
aspartic acid + H2O + NADP+
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64% of activity with pyruvate
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pyruvate + methylamine + NADPH
N-methyl-L-alanine + H2O + NADP+
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reverse reaction only to limited extend at very low rate
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r
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pyruvate + methylamine + NADPH
N-methyl-L-alanine + H2O + NADP+
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reverse reaction only to limited extend at very low rate
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r
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NADPH
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substrate inhibition above 1 mM
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2-mercaptoethanol
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required for full activity
dithiothreitol
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can replace 2-mercaptoethanol
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MS ATCC 25262
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brenda
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PY2CR_PSEPU
341
0
35973
Swiss-Prot
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PY2CR_PSEUB
343
0
36249
Swiss-Prot
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G8Q0U6_PSEO1
Pseudomonas ogarae (strain DSM 112162 / CECT 30235 / F113)
343
0
36170
TrEMBL
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dimer
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2 * 36500, SDS-PAGE, gel filtration
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unstable in the absence of 2-mercaptoethanol or dithiothreitol
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Lin, M.C.M.; Wagner, C.
Purification and characterization of N-methylalanine dehydrogenase
J. Biol. Chem.
250
3746-3751
1975
Pseudomonas sp.
brenda
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