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The expected taxonomic range for this enzyme is: Lyngbya majuscula
Synonyms
curacin enoyl reductase,
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curacin enoyl reductase
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(2E,4E,6E,10Z)-4-methyl-11-[2-[(1R,2S)-2-methylcyclopropyl]-4,5-dihydro-1,3-thiazol-4-yl]undeca-2,4,6,10-tetraenoyl-[acyl-carrier-protein] + NADPH + H+ = (2E,4E,6E,10Z)-4-methyl-11-[2-[(1R,2S)-2-methylcyclopropyl]-4,5-dihydro-1,3-thiazol-4-yl]undeca-4,6,10-trienoyl-[acyl-carrier-protein] + NADP+
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(2E,4E,6E,10Z)-4-methyl-11-[2-[(1R,2S)-2-methylcyclopropyl]-4,5-dihydro-1,3-thiazol-4-yl]undeca-4,6,10-trienoyl-[acyl-carrier-protein]: NADP+ oxidoreductase
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(2E,4E,6E,10Z)-4-methyl-11-[2-[(1R,2S)-2-methylcyclopropyl]-4,5-dihydro-1,3-thiazol-4-yl]undeca-2,4,6,10-tetraenoyl-[acyl-carrier-protein] + NADPH + H+
(2E,4E,6E,10Z)-4-methyl-11-[2-[(1R,2S)-2-methylcyclopropyl]-4,5-dihydro-1,3-thiazol-4-yl]undeca-4,6,10-trienoyl-[acyl-carrier-protein] + NADP+
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crotonyl-CoA + NADPH + H+
butanoyl-CoA + NADP+
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(2E,4E,6E,10Z)-4-methyl-11-[2-[(1R,2S)-2-methylcyclopropyl]-4,5-dihydro-1,3-thiazol-4-yl]undeca-2,4,6,10-tetraenoyl-[acyl-carrier-protein] + NADPH + H+
(2E,4E,6E,10Z)-4-methyl-11-[2-[(1R,2S)-2-methylcyclopropyl]-4,5-dihydro-1,3-thiazol-4-yl]undeca-4,6,10-trienoyl-[acyl-carrier-protein] + NADP+
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NADPH
loops that contact NADPH show flexibility
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UniProt
brenda
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physiological function
enzyme is involved in biosynthesis of anticancer agent curacin A
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Q6DNE2_9CYAN
2232
0
245991
TrEMBL
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Khare, D.; Hale, W.; Tripathi, A.; Gu, L.; Sherman, D.; Gerwick, W.; Hakansson, K.; Smith, J.
Structural basis for cyclopropanation by a unique enoyl-acyl carrier protein reductase
Structure
23
2213-2223
2015
Lyngbya majuscula (Q6DNE2)
brenda
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1.3.1.B14 curacin A enoyl-acyl carrier protein reductase
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