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3,3',5'-triido-L-thyronine + AH
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triido-L-thyronine + iodide + A + H+
L-thyroxine + AH2
-
assay at pH 7.2
-
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+
L-thyroxine + reduced acceptor
3,3',5'-triiodo-L-thyronine + reduced acceptor
3,3'-diiodo-L-thyronine + iodide + acceptor + H+
-
-
-
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
?
3,3',5-triiodo-L-thyronine + AH2
?
-
assay at pH 7.0, 37°C
-
-
?
3,3',5-triiodo-L-thyronine sulfate + AH2
3,3'-diiodo-L-thyronine sulfate + iodide + A + H+
3,5,3'-triiodo-L-thyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
3,5,3'-triiodo-L-thyronine + AH2
?
-
-
-
?
3,5,3'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
radioactive and unlabeled T3,in presence of 1 6-N-propylthiouracil, the products of deiodination are quantified by HPLC
-
-
?
L-3',5'-diiodothyronine + AH2
L-5'-iodothyronine + iodide + A + H+
L-3,5,3',5'-tetraiodothyronine + AH2
L-3,5',3'-triiodothyronine + iodide + A + H+
-
i.e. thyroxine, reaction of isozyme Dio3
i.e. reverse triiodothyrosine
-
?
L-3,5,3'-triiodothyronine + AH2
L-3,3'-diiodothyronine + iodide + A + H+
-
5-deionination by isozyme Dio1
-
-
?
L-3-iodothyronine + AH2
L-thyronine + iodide + A + H+
L-thyroxine + AH2
3,3',5'-triido-L-thyronine + iodide + A + H+
-
-
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
-
-
-
?
L-thyroxine + reduced acceptor
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+
-
-
-
-
?
additional information
?
-
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
prefers T3 over T4 as substrate, bisubstrate sequential-type reaction mechanism
-
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
D3 terminates thyroid hormone action by by inactivating T3
-
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
type 3 deiodinase terminates thyroid hormone action by inactivating T3
-
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
no activity
-
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
preferred substrate
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
type I isozyme
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
type I isozyme
-
-
?
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+
L-thyroxine + reduced acceptor
-
-
-
?
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+
L-thyroxine + reduced acceptor
-
-
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
hormonally inactive
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
best substrate
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
hormonally inactive, i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
hormonally inactive
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
best substrate
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
isozyme type III
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
hormonally inactive
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
selenocysteine residue in the active site is essential for efficient inner ring deiodination
i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
hormonally inactive, i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
best substrate
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
best substrate
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
hormonally inactive
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
best substrate
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
isozyme type III
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
-
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
hormonally inactive
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
best substrate
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
best substrate
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
best substrate
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
best substrate
hormonally inactive
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
hormonally inactive
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
isozyme type III
hormonally inactive
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
no detectable activity in vivo, isozyme type III
-
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
hormonally inactive
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
isozyme type III
-
-
?
3,3',5-triiodo-L-thyronine sulfate + AH2
3,3'-diiodo-L-thyronine sulfate + iodide + A + H+
isozyme type III
-
-
?
3,3',5-triiodo-L-thyronine sulfate + AH2
3,3'-diiodo-L-thyronine sulfate + iodide + A + H+
about 14% of the activity with 3,3',5-triiodo-L-thyronine
-
-
?
3,5,3'-triiodo-L-thyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,5,3'-triiodo-L-thyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
highest substrate affinity for 3,5,3'-triiodo-L-thyronine
-
-
?
3,5,3'-triiodo-L-thyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
L-3',5'-diiodothyronine + AH2
L-5'-iodothyronine + iodide + A + H+
-
phenolic ring deiodination of 3',5'-T2 by Dio2
-
-
?
L-3',5'-diiodothyronine + AH2
L-5'-iodothyronine + iodide + A + H+
-
phenolic ring deiodination of 3',5'-T2 by Dio2
-
-
?
L-3-iodothyronine + AH2
L-thyronine + iodide + A + H+
-
tyrosyl ring deiodination of 3-iodothyronamine by isozyme Dio3
-
-
?
L-3-iodothyronine + AH2
L-thyronine + iodide + A + H+
-
tyrosyl ring deiodination of 3-iodothyronamine by isozyme Dio3
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
enzyme performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
preferred substrate
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
preferred substrate
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
isozyme type III
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozyme type III
hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
hormonally inactive, enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
5-deiodinase activity
enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
selenocysteine residue in the active site is absolutely essential for efficient inner ring deiodination
enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
enzyme III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
enzyme performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
preferred substrate
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
in pre- and prometamorphic tadpoles, undetectable during metamorphic climax
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
enzyme III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
enzyme performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
very low activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
isozyme type III
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
preferred substrate
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
-
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
preferred substrate
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
preferred substrate
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
preferred substrate
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
preferred substrate
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
preferred substrate
hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
type I isozyme
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
isozyme type III
hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
5-deiodinase activity
hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
from microsomal enzyme complex, 3,3',5'-triiodo-L-thyronine is regulatory active
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
i.e. 3,3',5,5'-tetraiodo-L-thyronine
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
enzyme performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
enzyme performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
enzyme III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
enzyme performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
low activity
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
5'-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
in vivo after entering metamorphic climax, low 5'-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
no activity
-
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
preferred substrate
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
preferred substrate
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
5'-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
5'-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
5'-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
5'-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
5'-deiodinase activity
from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
isozyme type II
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
isozyme type I
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
isozyme type I
-
?
additional information
?
-
-
isozyme type III predominantly performs 5-deiodination reactions, while isozymes type I and type II perform 5'-deiodination reactions
-
-
?
additional information
?
-
-
enzyme performs inactivation of thyroid hormones
-
-
?
additional information
?
-
-
isozyme type III is a oncofetal enzyme, regulation
-
-
?
additional information
?
-
-
isozyme type III predominantly performs 5-deiodination reactions, while isozymes type I and type II perform 5'-deiodination reactions
-
-
?
additional information
?
-
-
isozyme type III is a oncofetal enzyme, regulation
-
-
?
additional information
?
-
-
thyroid hormone is essential for maintaining normal neurological functions both during development and in adult life
-
-
?
additional information
?
-
-
the enzyme is the major physiological inactivator of thyroid hormone. The presence of the enzyme at maternal-fetal interfaces is consistent with its role in modulating the thyroid status of the human fetus and its expression in endometrium suggests that local regulation of thyroid status is important in implantation
-
-
?
additional information
?
-
-
isozyme type III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
additional information
?
-
-
selenium-level of cells influences the enzyme activity
-
-
?
additional information
?
-
-
thyronines and thyronamines are two groups of endogenous iodine-containing signaling molecules that are substrates of three deiodinase isozymes, which catalyze the sequential reductive removal of iodine from the respective precursor molecule. Development of a analytical method applying liquid chromatography/tandem mass spectrometry, overview
-
-
?
additional information
?
-
-
isozyme Dio1 exhibits both phenolic and tyrosyl ring deiodination activity while isozyme Dio2 catalyzes only deiodinations of the phenolic ring, isozyme Dio3 catalyzes only deiodinations of the tyrosyl ring. T3, 3,3'-T2, and 3,5-T2 are also not deiodinated by Dio1 from HepG2 lysates
-
-
?
additional information
?
-
-
isozyme type III predominantly performs 5-deiodination reactions, while isozymes type I and type II perform 5'-deiodination reactions
-
-
?
additional information
?
-
-
enzyme activity is developmentally regulated, overview
-
-
?
additional information
?
-
-
isozyme type III is a oncofetal enzyme, regulation
-
-
?
additional information
?
-
-
isozyme type III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
additional information
?
-
-
thyronines and thyronamines are two groups of endogenous iodine-containing signaling molecules that are substrates of three deiodinase isozymes, which catalyze the sequential reductive removal of iodine from the respective precursor molecule. Development of a analytical method applying liquid chromatography/tandem mass spectrometry, overview
-
-
?
additional information
?
-
-
isozyme Dio1 from mouse liver membrane fractions catalyzes a weak 3'-deiodination of 3,3'-T2 as well as faint 5-deiodinations of both T3 and 3,5-T2
-
-
?
additional information
?
-
-
isozyme type III predominantly performs 5-deiodination reactions, while isozymes type I and type II perform 5'-deiodination reactions
-
-
?
additional information
?
-
-
isozyme type III is a oncofetal enzyme, regulation
-
-
?
additional information
?
-
-
isozyme type III predominantly performs 5-deiodination reactions, while isozymes type I and type II perform 5'-deiodination reactions
-
-
?
additional information
?
-
-
isozyme type III predominantly performs 5-deiodination reactions, while isozymes type I and type II perform 5'-deiodination reactions
-
-
?
additional information
?
-
-
enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
additional information
?
-
-
5-deiodinase activity in brain is slightly decreased in hypo- and slightly increased in hyperthyroidism
-
-
?
additional information
?
-
-
placental isozyme type III is only slightly increased in hyperthyroidism, while brain isozyme type III is strongly induced
-
-
?
additional information
?
-
-
enzyme performs inactivation of thyroid hormones
-
-
?
additional information
?
-
-
isozyme type III is a oncofetal enzyme, regulation
-
-
?
additional information
?
-
-
L-hormone analogues are preferentially deiodinated via the T4-5'-deiodination pathway, whereas D-analogues produce products via the T4-5-deiodination pathway
-
-
?
additional information
?
-
-
isozyme type III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+
L-thyroxine + reduced acceptor
3,3',5'-triiodo-L-thyronine + reduced acceptor
3,3'-diiodo-L-thyronine + iodide + acceptor + H+
-
-
-
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
-
-
-
?
L-thyroxine + reduced acceptor
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+
-
-
-
-
?
additional information
?
-
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+
L-thyroxine + reduced acceptor
-
-
-
?
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+
L-thyroxine + reduced acceptor
-
-
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
hormonally inactive, i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
hormonally inactive
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
selenocysteine residue in the active site is essential for efficient inner ring deiodination
i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
hormonally inactive, i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
hormonally inactive
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
hormonally inactive
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
hormonally inactive, i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
no detectable activity in vivo, isozyme type III
-
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
hormonally inactive
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
hormonally inactive, enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
5-deiodinase activity
enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
selenocysteine residue in the active site is absolutely essential for efficient inner ring deiodination
enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
enzyme III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
in pre- and prometamorphic tadpoles, undetectable during metamorphic climax
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
enzyme III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
-
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
from microsomal enzyme complex, 3,3',5'-triiodo-L-thyronine is regulatory active
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
enzyme performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
enzyme III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
5'-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
in vivo after entering metamorphic climax, low 5'-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
5'-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
5'-deiodinase activity
from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active
?
additional information
?
-
-
enzyme performs inactivation of thyroid hormones
-
-
?
additional information
?
-
-
isozyme type III is a oncofetal enzyme, regulation
-
-
?
additional information
?
-
-
isozyme type III is a oncofetal enzyme, regulation
-
-
?
additional information
?
-
-
thyroid hormone is essential for maintaining normal neurological functions both during development and in adult life
-
-
?
additional information
?
-
-
the enzyme is the major physiological inactivator of thyroid hormone. The presence of the enzyme at maternal-fetal interfaces is consistent with its role in modulating the thyroid status of the human fetus and its expression in endometrium suggests that local regulation of thyroid status is important in implantation
-
-
?
additional information
?
-
-
isozyme type III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
additional information
?
-
-
thyronines and thyronamines are two groups of endogenous iodine-containing signaling molecules that are substrates of three deiodinase isozymes, which catalyze the sequential reductive removal of iodine from the respective precursor molecule. Development of a analytical method applying liquid chromatography/tandem mass spectrometry, overview
-
-
?
additional information
?
-
-
enzyme activity is developmentally regulated, overview
-
-
?
additional information
?
-
-
isozyme type III is a oncofetal enzyme, regulation
-
-
?
additional information
?
-
-
isozyme type III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
additional information
?
-
-
thyronines and thyronamines are two groups of endogenous iodine-containing signaling molecules that are substrates of three deiodinase isozymes, which catalyze the sequential reductive removal of iodine from the respective precursor molecule. Development of a analytical method applying liquid chromatography/tandem mass spectrometry, overview
-
-
?
additional information
?
-
-
isozyme type III is a oncofetal enzyme, regulation
-
-
?
additional information
?
-
-
enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
additional information
?
-
-
5-deiodinase activity in brain is slightly decreased in hypo- and slightly increased in hyperthyroidism
-
-
?
additional information
?
-
-
placental isozyme type III is only slightly increased in hyperthyroidism, while brain isozyme type III is strongly induced
-
-
?
additional information
?
-
-
enzyme performs inactivation of thyroid hormones
-
-
?
additional information
?
-
-
isozyme type III is a oncofetal enzyme, regulation
-
-
?
additional information
?
-
-
L-hormone analogues are preferentially deiodinated via the T4-5'-deiodination pathway, whereas D-analogues produce products via the T4-5-deiodination pathway
-
-
?
additional information
?
-
-
isozyme type III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(2E)-2-(3,4-dihydroxybenzylidene)-4,6-dihydroxy-1-benzofuran-3(2H)-one
-
aurone derivative isolated from plant extract. Comparison with inhibition of 5'-deiodinase EC 1.97.1.10
(2E)-2-(3,4-dihydroxybenzylidene)-6-hydroxy-1-benzofuran-3(2H)-one
-
aurone derivative isolated from plant extract. Comparison with inhibition of 5'-deiodinase EC 1.97.1.10
(2E)-4,6-dihydroxy-2-(4-hydroxy-3-iodobenzylidene)-1-benzofuran-3(2H)-one
-
aurone derivative isolated from plant extract. Comparison with inhibition of 5'-deiodinase EC 1.97.1.10
(2E)-4,6-dihydroxy-2-(4-hydroxybenzylidene)-1-benzofuran-3(2H)-one
-
aurone derivative isolated from plant extract. Comparison with inhibition of 5'-deiodinase EC 1.97.1.10
(4-[(E)-(4,6-dihydroxy-3-oxo-1-benzofuran-2(3H)-ylidene)methyl]phenoxy)acetic acid
-
aurone derivative isolated from plant extract. Comparison with inhibition of 5'-deiodinase EC 1.97.1.10
2-(3,4-dihydroxybenzyl)-4,6-dihydroxy-1-benzofuran-3(2H)-one
-
aurone derivative isolated from plant extract. Comparison with inhibition of 5'-deiodinase EC 1.97.1.10
3',4',4,6-tetrahydroxyaurone
-
inhibition kinetics; very potent naturally occuring plant-derived inhibitor, conformation study
3',5'-diiodothyronine
-
comparison with 5'-deiodinase EC 1.97.1.10
3,3',5'-triiodo-L-thyronine
3,3',5'-triiodothyronine
-
comparison with 5'-deiodinase EC 1.97.1.10
3,3',5,5'-tetraiodo-L-thyronine
3,3',5-triiodo-L-thyronine
3,3'-diiodo-L-thyronine
-
product inhibition, 82% at 0.001 mM
3,5,3'-triiodo-5'-nitrothyronine
-
comparison with 5'-deiodinase EC 1.97.1.10
3,5,5'-triiodo-2'-methylthyronine
-
comparison with 5'-deiodinase EC 1.97.1.10
3,5-diiodo-2'-hydroxythyronine
-
comparison with 5'-deiodinase EC 1.97.1.10
3,5-diiodo-3',5'-dinitrothyronine
-
comparison with 5'-deiodinase EC 1.97.1.10
3,5-diiodo-3'-hydroxythyronine
-
comparison with 5'-deiodinase EC 1.97.1.10
3,5-diiodo-4'-amino-3',5'-dimethylthyronine
-
comparison with 5'-deiodinase EC 1.97.1.10
4',4,6-trihydroxyaurone
-
cofactor competitive mechanism, displacement of thyroxine from the binding site of thyroxine-binding prealbumin; inhibition kinetics; very potent naturally occuring plant-derived inhibitor
6-n-propyl-2-thiouracil
type 3 iodothyronine deiodinase is unaffected by PTU
bromoacetyl-triiodothyronine
-
-
cycloheximide
-
isozyme type III, slight decrease of activity in vivo
growth hormone
upregulates the 5-deiodinase mRNA expression in the tail, but downregulates it in the liver
-
iodoacetate
recombinant and native isozyme type III
luteolin-7-beta-glucoside
-
-
N-acetyl-3,5,3'-triiodo-5'-nitrothyronine
-
comparison with 5'-deiodinase EC 1.97.1.10
N-acetyl-3,5-diiodo-3',5'-dinitrothyronine
-
comparison with 5'-deiodinase EC 1.97.1.10
N-acetyl-3,5-diiodo-3'-bromo-5'-nitrothyronine
-
comparison with 5'-deiodinase EC 1.97.1.10
N-bromoacetyl-3,3',5-triiodo-L-thyronine
prolactin
inhibits the 3,3',5-triiodo-L-thyronine-dependent upregulation of thyroid hormone receptor beta mRNA expression in the tail; inhibits the regression of the tail fin; upregulates the 5-deiodinase mRNA expression in the tail, but downregulates it in the liver
-
propylthiouracil
slight inhibition of recombinant and native isozyme type III
sodium iodate
-
95% inhibition at 1 mM
Tetraiodothyroacetic acid
-
comparison with 5'-deiodinase EC 1.97.1.10
[4-(4-hydroxy-3,5-diiodophenoxy)phenyl]acetic acid
-
comparison with 5'-deiodinase EC 1.97.1.10
[4-(4-hydroxy-3,5-dinitrophenoxy)-3,5-diiodophenyl]acetic acid
-
comparison with 5'-deiodinase EC 1.97.1.10
[4-(4-hydroxy-3-iodo-5-nitrophenoxy)-3,5-diiodophenyl]acetic acid
-
comparison with 5'-deiodinase EC 1.97.1.10
[4-(4-hydroxy-3-iodo-5-nitrophenoxy)phenyl]acetic acid
-
comparison with 5'-deiodinase EC 1.97.1.10
3,3',5'-triiodo-L-thyronine
-
no effect up to 100 nM
3,3',5'-triiodo-L-thyronine
-
75% inhibition at 0.01 mM; substrate inhibition
3,3',5'-triiodo-L-thyronine
-
substrate inhibition
3,3',5,5'-tetraiodo-L-thyronine
-
substrate inhibition of isozyme type III
3,3',5,5'-tetraiodo-L-thyronine
-
95% substrate inhibition at 0.001 mM
3,3',5-triiodo-L-thyronine
-
substrate inhibition of isozyme type III, complete inhibition at 25 nM
3,3',5-triiodo-L-thyronine
-
substrate inhibition, completely at 0.001 mM
3,3',5-triiodo-L-thyronine
isozyme type III, inhibition of tail growth
3,5-diiodo-L-thyronine
-
substrate inhibition of isozyme type III
3,5-diiodo-L-thyronine
-
75% inhibition of 3,3'-diiodo-L-thyronine formation at 0.001 mM
aurothioglucose
-
3,3',5,5'-tetraiodo-L-thyronine 5-deiodinase activity
aurothioglucose
-
isozyme type III, 90% inhibition at 0.001 mM
aurothioglucose
recombinant and native isozyme type III
aurothioglucose
-
noncompetitive
aurothioglucose
no inhibition, isozyme type III
aurothioglucose
-
no inhibition, isozyme type III
iopanoic acid
-
iopanoic acid
-
3,3',5,5'-tetraiodo-L-thyronine 5-deiodinase activity
iopanoic acid
-
90% inhibition at 0.002 mM; isozyme type III
iopanoic acid
isozyme type III; tail growth inhibition
N-bromoacetyl-3,3',5-triiodo-L-thyronine
-
irreversible inactivation; isozyme type III; reacts with the selenocysteine residue in the active site
N-bromoacetyl-3,3',5-triiodo-L-thyronine
-
irreversible inactivation; isozyme type III; reacts with the selenocysteine residue in the active site
Phospholipids
-
possible regulatory role
Phospholipids
-
no inhibition of placental isozyme type III
additional information
the measured zD3 activity is unaffected by 1 mM propylthiouracil
-
additional information
-
no inhibition of 5-deiodinase activity by propylthiouracil
-
additional information
-
3,3',5-triiodo-L-thyronine sulfate has no effect on isozyme type III in hippocampus up to 100 nM
-
additional information
-
expression and function of the 5-deiodinase and 5-deiodinase isozymes are sensitive to thyroid hormone status, various cytokines and growth factors, severe illness, reactive oxygen species, a variety of hormones and signaling compounds, circadian rythm, and pharmacological agents, and therefore might be useful in sensor function of physiology and pathophysiology
-
additional information
-
decrease of deiodination about 50% in cells with knockdown of peroxiredoxin 3
-
additional information
no inhibition of 5-deiodinase activity by propylthiouracil
-
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Homo sapiens
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Homo sapiens (P55073), Homo sapiens
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Homo sapiens
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Rattus norvegicus
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Homo sapiens
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Homo sapiens
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-
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The 5-deiodinases are not essential for the fasting-induced decrease in circulating thyroid hormone levels in male mice: possible roles for the type 3 deiodinase and tissue sequestration of hormone
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2014
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115
2013
Homo sapiens (P55073)
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115
22-28
2014
Mus musculus (Q91ZI8), Mus musculus
brenda
Schweizer, U.; Schlicker, C.; Braun, D.; Khrle, J.; Steegborn, C.
Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism
Proc. Natl. Acad. Sci. USA
111
10526-10531
2014
Mus musculus (Q91ZI8), Mus musculus
brenda
Stevenson, T.; Onishi, K.; Bradley, S.; Prendergast, B.
Cell-autonomous iodothyronine deiodinase expression mediates seasonal plasticity in immune function
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36
61-70
2014
Phodopus sungorus
brenda
Fortino, M.; Marino, T.; Russo, N.; Sicilia, E.
Mechanism of thyroxine deiodination by naphthyl-based iodothyronine deiodinase mimics and the halogen bonding role a DFT investigation
Chemistry
21
8554-8560
2015
Homo sapiens
brenda
Wu, Z.; Martinez, M.E.; St Germain, D.L.; Hernandez, A.
Type 3 deiodinase role on central thyroid hormone action affects the leptin-melanocortin system and circadian activity
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158
419-430
2017
Mus musculus
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Schweizerulrich U, S.U.; Steegborn C, S.C.
New insights into the structure and mechanism of iodothyronine deiodinases
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55
T37-T52
2015
Mus musculus
brenda
Schweizer, U.; Schlicker, C.; Braun, D.; Khrle, J.; Steegborn, C.
Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism
Proc. Natl. Acad. Sci. USA
111
10526-10531
2014
Mus musculus (Q91ZI8), Mus musculus
brenda