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Information on EC 1.14.20.11 - 3-[(Z)-2-isocyanoethenyl]-1H-indole synthase

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IUBMB Comments
The enzyme, characterized from the cyanobacterium Fischerella ambigua UTEX 1903, participates in the biosynthesis of hapalindole-type alkaloids. The enzyme catalyses an Fe2+, 2-oxoglutarate-dependent monooxygenation at C-3, which is followed by decarboxylation and dehydration, resulting in the generation of a cis C-C double bond. cf. EC 1.14.20.12, 3-[(E)-2-isocyanoethenyl]-1H-indole synthase.
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The expected taxonomic range for this enzyme is: Fischerella ambigua
Synonyms
ambi3, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + O2 = 3-[(Z)-2-isocyanoethenyl]-1H-indole + succinate + 2 CO2 + H2O
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PATHWAY SOURCE
PATHWAYS
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