Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase deficiency
Central nervous system dysfunction in a mouse model of FA2H deficiency.
4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase deficiency
Exome sequencing and SNP analysis detect novel compound heterozygosity in fatty acid hydroxylase-associated neurodegeneration.
4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase deficiency
FAHN/SPG35: a narrow phenotypic spectrum across disease classifications.
4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase deficiency
Fatty acid 2-hydroxylase deficiency: Clinical features and brain iron accumulation.
Adenocarcinoma
High FA2H and UGT8 transcript levels predict hydroxylated hexosylceramide accumulation in lung adenocarcinoma.
Adenocarcinoma of Lung
High FA2H and UGT8 transcript levels predict hydroxylated hexosylceramide accumulation in lung adenocarcinoma.
Alopecia
Normal fur development and sebum production depends on Fatty Acid 2-hydroxylase expression in sebaceous glands.
Breast Neoplasms
?(9)-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression: possible involvement of induced levels of PPAR? in MDA-MB-231 breast cancer cells.
Breast Neoplasms
?9-Tetrahydrocannabinol upregulates fatty acid 2-hydroxylase (FA2H) via PPAR? induction: A possible evidence for the cancellation of PPAR?/?-mediated inhibition of PPAR? in MDA-MB-231?cells.
Breast Neoplasms
FA2H Exhibits Tumor Suppressive Roles on Breast Cancers via Cancer Stemness Control.
Breast Neoplasms
Fatty acid 2-hydroxylase (FA2H) as a stimulatory molecule responsible for breast cancer cell migration.
Breast Neoplasms
Induction of the fatty acid 2-hydroxylase (FA2H) gene by ?(9)-tetrahydrocannabinol in human breast cancer cells.
Carcinoma, Hepatocellular
Elevated expression of A-Raf and FA2H in hepatocellular carcinoma is associated with lipid metabolism dysregulation and cancer progression.
Carcinoma, Neuroendocrine
High FA2H and UGT8 transcript levels predict hydroxylated hexosylceramide accumulation in lung adenocarcinoma.
Cholera
Fatty acid 2-hydroxylase mediates diffusional mobility of Raft-associated lipids, GLUT4 level, and lipogenesis in 3T3-L1 adipocytes.
Colorectal Neoplasms
2-Hydroxylation of Fatty Acids Represses Colorectal Tumorigenesis and Metastasis via the YAP Transcriptional Axis.
Congenital Abnormalities
FAHN/SPG35: a narrow phenotypic spectrum across disease classifications.
Demyelinating Diseases
2'-Hydroxy ceramide in membrane homeostasis and cell signaling.
Demyelinating Diseases
FAHN/SPG35: a narrow phenotypic spectrum across disease classifications.
Dystonia
FA2H-related disorders: a novel c.270+3A>T splice-site mutation leads to a complex neurodegenerative phenotype.
Dystonia
Mutations in the fatty acid 2-hydroxylase gene are associated with leukodystrophy with spastic paraparesis and dystonia.
Dystonia
Novel Mutations in FA2H-Associated Neurodegeneration: An Underrecognized Condition?
Genetic Diseases, Inborn
Iron dysregulation in movement disorders.
Hereditary Sensory and Motor Neuropathy
Genetic and phenotypic characterization of complex hereditary spastic paraplegia.
Insulin Resistance
Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075.
Leukoencephalopathies
Mutations in the fatty acid 2-hydroxylase gene are associated with leukodystrophy with spastic paraparesis and dystonia.
Lung Neoplasms
High FA2H and UGT8 transcript levels predict hydroxylated hexosylceramide accumulation in lung adenocarcinoma.
Movement Disorders
The Interaction of Genetic Mutations in PARK2 and FA2H Causes a Novel Phenotype in a Case of Childhood-Onset Movement Disorder.
Neoplasm Metastasis
Fatty acid 2-hydroxylation inhibits tumor growth and increases sensitivity to cisplatin in gastric cancer.
Neoplasms
2-Hydroxylation of Fatty Acids Represses Colorectal Tumorigenesis and Metastasis via the YAP Transcriptional Axis.
Neoplasms
Elevated expression of A-Raf and FA2H in hepatocellular carcinoma is associated with lipid metabolism dysregulation and cancer progression.
Neoplasms
FA2H Exhibits Tumor Suppressive Roles on Breast Cancers via Cancer Stemness Control.
Neoplasms
Fatty acid 2-hydroxylase (FA2H) as a stimulatory molecule responsible for breast cancer cell migration.
Neoplasms
Fatty acid 2-hydroxylation inhibits tumor growth and increases sensitivity to cisplatin in gastric cancer.
Neoplasms
High FA2H and UGT8 transcript levels predict hydroxylated hexosylceramide accumulation in lung adenocarcinoma.
Neoplasms
Levels of SCS7/FA2H-mediated fatty acid 2-hydroxylation determine the sensitivity of cells to antitumor PM02734.
Neoplasms
Overexpression of Fatty Acid 2-Hydroxylase is Associated with an Increased Sensitivity to Cisplatin by Ovarian Cancer and Better Prognoses.
Neurilemmoma
2'-Hydroxy ceramide in membrane homeostasis and cell signaling.
Neurilemmoma
Fatty acid 2-hydroxylase regulates cAMP-induced cell cycle exit in D6P2T Schwannoma cells.
Neuroaxonal Dystrophies
Excess iron harms the brain: the syndromes of neurodegeneration with brain iron accumulation (NBIA).
Neuroaxonal Dystrophies
Genetics and Pathophysiology of Neurodegeneration with Brain Iron Accumulation (NBIA).
Neurodegenerative Diseases
2-hydroxylated sphingomyelin profiles in cells from patients with mutated fatty acid 2-hydroxylase.
Neurodegenerative Diseases
FA2H-related disorders: a novel c.270+3A>T splice-site mutation leads to a complex neurodegenerative phenotype.
Neuronal Ceroid-Lipofuscinoses
Genetic and phenotypic characterization of complex hereditary spastic paraplegia.
Ovarian Neoplasms
Overexpression of Fatty Acid 2-Hydroxylase is Associated with an Increased Sensitivity to Cisplatin by Ovarian Cancer and Better Prognoses.
Pantothenate Kinase-Associated Neurodegeneration
Excess iron harms the brain: the syndromes of neurodegeneration with brain iron accumulation (NBIA).
Pantothenate Kinase-Associated Neurodegeneration
Genetics and Pathophysiology of Neurodegeneration with Brain Iron Accumulation (NBIA).
Paraparesis, Spastic
Atypical adult onset complicated spastic paraparesis with thin corpus callosum in two patients carrying a novel FA2H mutation.
Paraparesis, Spastic
EX-HOM (EXome HOMozygosity): A Proof of Principle.
Paraparesis, Spastic
FA2H-related disorders: a novel c.270+3A>T splice-site mutation leads to a complex neurodegenerative phenotype.
Paraparesis, Spastic
Fatty acid 2-Hydroxylation in mammalian sphingolipid biology.
Paraparesis, Spastic
Mutations in FA2H in three Arab families with a clinical spectrum of neurodegeneration and hereditary spastic paraparesis.
Paraparesis, Spastic
Mutations in the fatty acid 2-hydroxylase gene are associated with leukodystrophy with spastic paraparesis and dystonia.
Paraparesis, Spastic
The Crystal Structure of an Integral Membrane Fatty Acid ?-Hydroxylase.
Paraplegia
Autosomal recessive hereditary spastic paraplegia type SPG35 due to a novel variant in the FA2H gene in a Czech patient.
Paraplegia
Central nervous system dysfunction in a mouse model of FA2H deficiency.
Paraplegia
Decreased turnover of the CNS myelin protein Opalin in a mouse model of hereditary spastic paraplegia 35.
Paraplegia
Exome sequencing and SNP analysis detect novel compound heterozygosity in fatty acid hydroxylase-associated neurodegeneration.
Paraplegia
Exome sequencing of a Pakistani family with spastic paraplegia identified an 18 bp deletion in the cytochrome B5 domain of FA2H.
Paraplegia
FA2H-related disorders: a novel c.270+3A>T splice-site mutation leads to a complex neurodegenerative phenotype.
Paraplegia
Genetic and phenotypic characterization of complex hereditary spastic paraplegia.
Paraplegia
Hereditary spastic paraplegia type 35 caused by a novel FA2H mutation.
Paraplegia
Novel biallelic FA2H mutations in a Japanese boy with fatty acid hydroxylase-associated neurodegeneration.
Paraplegia
Novel FA2H mutation in a girl with familial spastic paraplegia.
Paraplegia
Novel Mutations in FA2H-Associated Neurodegeneration: An Underrecognized Condition?
Prostatic Neoplasms
Identification of a Robust Five-Gene Risk Model in Prostate Cancer: A Robust Likelihood-Based Survival Analysis.
Spastic Paraplegia, Hereditary
A p.Arg499His Mutation in SPAST Is Associated with Infantile Onset Ascending Spastic Paralysis Complicated with Dysarthria and Anarthria.
Spastic Paraplegia, Hereditary
A rare family with Hereditary Spastic Paraplegia Type 35 due to novel FA2H mutations: a case report with literature review.
Spastic Paraplegia, Hereditary
Autosomal recessive hereditary spastic paraplegia type SPG35 due to a novel variant in the FA2H gene in a Czech patient.
Spastic Paraplegia, Hereditary
Defective FA2H leads to a novel form of neurodegeneration with brain iron accumulation (NBIA).
Spastic Paraplegia, Hereditary
Exome sequencing reveals two FA2H mutations in a family with a complicated form of Hereditary Spastic Paraplegia and psychiatric impairments.
Spastic Paraplegia, Hereditary
Hereditary spastic paraplegia type 35 caused by a novel FA2H mutation.
Spastic Paraplegia, Hereditary
Hereditary spastic paraplegia type 35 in a family from Mali.
Spastic Paraplegia, Hereditary
Hereditary Spastic Paraplegia Type 35 with a Novel Mutation in Fatty Acid 2-Hydroxylase Gene and Literature Review of the Clinical Features.
Spastic Paraplegia, Hereditary
Identification of progesterone receptor membrane component-1 as an interaction partner and possible regulator of fatty acid 2-hydroxylase.
Spastic Paraplegia, Hereditary
Mutation of FA2H underlies a complicated form of hereditary spastic paraplegia (SPG35).
Spastic Paraplegia, Hereditary
Phenotypic variability of a likely FA2H founder mutation in a family with complicated hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
SPG35 contributes to the second common subtype of AR-HSP in China: frequency analysis and functional characterization of FA2H gene mutations.
Spastic Paraplegia, Hereditary
The Interaction of Genetic Mutations in PARK2 and FA2H Causes a Novel Phenotype in a Case of Childhood-Onset Movement Disorder.
Spastic Paraplegia, Hereditary
Three faces of the same gene: FA2H links neurodegeneration with brain iron accumulation, leukodystrophies, and hereditary spastic paraplegias.
Spastic Paraplegia, Hereditary
Uniparental disomy of chromosome 16 unmasks recessive mutations of FA2H/SPG35 in 4 families.
Stomach Neoplasms
Fatty acid 2-hydroxylation inhibits tumor growth and increases sensitivity to cisplatin in gastric cancer.
Triple Negative Breast Neoplasms
FA2H Exhibits Tumor Suppressive Roles on Breast Cancers via Cancer Stemness Control.
Triple Negative Breast Neoplasms
Fatty acid 2-hydroxylase (FA2H) as a stimulatory molecule responsible for breast cancer cell migration.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
evolution
FA2H/Scs7p belongs to a superfamily of integral membrane di-iron-containing enzymes that hydroxylate or desaturate lipid-based substrates via a reaction mechanism that is dependent on NADH and oxygen
physiological function
-
a yeast strain that lacks the FAH1 gene is resistant to antifungal cyclic lipodepsinonapeptide syringomycin E
physiological function
COS7 cells expressing human FA2H contain 3-20fold higher levels of 2-hydroxyceramides (C16, C18, C24, and C24:1) and 2-hydroxy fatty acids compared with control cells
physiological function
-
Deletion of hydroxylase scs7 causes synthetic lethality in combination deletion of phosphoinositide phosphatase SAC1. Overexpression of PSS1 encoding phosphatidylserine synthase complements the growth defects of scs7 deletion cells under SAC1-repressive conditions, and overexpression of Arf-GAP AGE1, which encodes aprotein related to membrane trafficking, also complements
physiological function
disruption of the FAH1 gene does not give any visible phenotype, and there is no observable difference in content or distribution of the most abundant long chain saturated and unsaturated 14-18-carbon fatty acid species. The gene-disrupted DELTAfah1 strain shows an approximately 40fold reduction of alpha-hydroxy-fatty acid 26:0 and a complementary increase in fatty acid 26:0. Expression of Arabidopsis thaliana FAH1 gene, which does not contain the cytochrome b5 domain, in the Saccharomyces cerevisiae DELTAfah1 strain produces an approximately 25fold increase in alpha-hydroxyfatty acid 26:0 and reduces the levels of its 26-carbon precursor
physiological function
FA2H knockdown in adipocytes increases diffusional mobility of raft-associated lipids, leading to reduced GLUT4 protein level, glucose uptake, and lipogenesis
physiological function
FA2H-siRNA suppresses 2-hydroxylase activity and decreases 2-hydroxyceramide/2-hydroxyglucosylceramide levels. Keratinocytes transduced with FA2H-siRNA contain abnormal epidermal lamellar bodies and do not form the normal extracellular lamellar membranes required for the epidermal permeability barrier
physiological function
fatty acid 2-hydroxylase Fa2h/UDP-galactose:ceramide galactosyltransferase Cgt double-deficient mice lack sulfatide, GalCer, and in addition 2-hydroxylated fatty acid-galactosylceramide and sphingomyelin. Compared to Cgt-/- mice the amount of GlcCer in central nervous system myelin is strongly reduced in Fa2h-/-/Cgt-/- mice by more than 80%. This is accompanied by a significant increase in sphingomyelin, which is the predominant sphingolipid in Fa2h-/-/Cgt-/- mice. Compact myelin is formed in Fa2h-/-/Cgt-/- mice, and g-ratios of myelinated axons in the spinal cord of 4-week-old Fa2h-/-/Cgt-/- mice do not differ significantly from that of Cgt-/- mice, and there is no obvious phenotypic difference between Fa2h-/-/Cgt-/- and Cgt-/- mice
physiological function
mutants lacking Scs7 fail to accumulate the inositolphosphorylceramide species, IPC-C, which is the predominant form found in wild-type cells. Instead scs7 mutants accumulate an IPC-B species believed to be unhydroxylated on the amide-linked C26-fatty acid. Elimination of the gene suppresses the Ca2+-sensitive phenotype of csg1 and csg2 mutants. The CSG1 and CSG2 genes are required for mannosylation of IPC-C
physiological function
-
partial silencing of fatty acid 2-hydroxylase FA2H in D6P2T cells results in 60-70% reduction of hydroxyl fatty acid-dihydroceramide and hydroxyl fatty acid-ceramide, with no effect on nonhydroxy dihydroceramide and ceramide.Under these conditions, dibutyryl-cAMP no longer induces cell cycle exit, and cells continue to grow and divide. FA2H silencing prevents dibutyryl-cAMP-induced upregulation of cyclin-dependent kinase inhibitors p21 and p27
physiological function
silencing of sphingolipid fatty acyl 2-hydroxylase Fa2h turns the cells resistant to synthetic antitumor drug PM02734, i.e. elisidepsin. Overexpression of Fa2H leads to an increased sensitivity to PM02734
physiological function
silencing of sphingolipid fatty acyl 2-hydroxylase Scs7 turns the cells resistant to synthetic antitumor drug PM02734, i.e. elisidepsin. Overexpression of Scs7 renders the cells hypersensitive to PM02734
physiological function
transfection of FA2H cDNA in CHO cells leads to the formation of hexosylceramide containing alpha-hydroxylated fatty acid
physiological function
enzyme Scs7p is responsible for adding a hydroxyl group to the alpha-carbon of the VLCFA moiety of the ceramide substrate to generate inositol phosphoceramide, one of three major sphingolipids in yeast
physiological function
undifferentiated and differentiated Neuro2a cells are protected from mechanical, heat (42°C) and oxidative stress by nimodipine, or at least to a lower extent by nifedipine. Higher expression of enzyme FA2H induced by nimodipine may cause higher survival of Neuro2a cells stressed with surgery-like stressors
additional information
important role of the dimetal-binding histidines in catalysis, residues Tyr322 and Asp323 are critical determinants involved in the hydroxylase reaction. Molecular dynamics simulations, structure-function analysis, and generation of a model of ceramide binding to enzyme Scs7p
additional information
-
important role of the dimetal-binding histidines in catalysis, residues Tyr322 and Asp323 are critical determinants involved in the hydroxylase reaction. Molecular dynamics simulations, structure-function analysis, and generation of a model of ceramide binding to enzyme Scs7p
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
D323A
site-directed mutagenesis, the mutation results in partial loss of syringomycin E sensitivity
H173A
site-directed mutagenesis, the mutation results in partial loss of syringomycin E sensitivity
H244A
site-directed mutagenesis, the mutation results in major loss of syringomycin E sensitivity
H249A
site-directed mutagenesis, the mutation results in partial loss of syringomycin E sensitivity
H264A
site-directed mutagenesis, the mutation results in unaltered syringomycin E sensitivity compared to the wild-type
H268A
site-directed mutagenesis, the mutation results in partial loss of syringomycin E sensitivity
H271A
site-directed mutagenesis, the mutation results in major loss of syringomycin E sensitivity
H272A
site-directed mutagenesis, the mutation results in major loss of syringomycin E sensitivity
H326A
site-directed mutagenesis, the mutation results in major loss of syringomycin E sensitivity
H330A
site-directed mutagenesis, the mutation results in complete loss of syringomycin E sensitivity
H331A
site-directed mutagenesis, the mutation results in unaltered syringomycin E sensitivity compared to the wild-type
H345A
site-directed mutagenesis, the mutation results in major loss of syringomycin E sensitivity
H348A
site-directed mutagenesis, the mutation results in major loss of syringomycin E sensitivity
H349A
site-directed mutagenesis, the mutation results in major loss of syringomycin E sensitivity
Y319A
site-directed mutagenesis, the mutation results in unaltered syringomycin E sensitivity compared to the wild-type
Y322A
site-directed mutagenesis, the mutation results in major loss of syringomycin E sensitivity
additional information
FA2H lacking the N-terminal cytochrome b5 domain has little activity
additional information
-
FA2H lacking the N-terminal cytochrome b5 domain has little activity
additional information
generation of an scs7-DELTA strain from wild-type Saccharomyces cerevisiae strain BY4742. The model of DELTA95scScs7p mutant is inserted into a pre-equilibrated lipid bilayer comprised of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine
additional information
-
generation of an scs7-DELTA strain from wild-type Saccharomyces cerevisiae strain BY4742. The model of DELTA95scScs7p mutant is inserted into a pre-equilibrated lipid bilayer comprised of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Eckhardt, M.; Yaghootfam, A.; Fewou, S.; Zller, I.; Gieselmann, V.
A mammalian fatty acid hydroxylase responsible for the formation of alpha-hydroxylated galactosylceramide in myelin
Biochem. J.
388
245-254
2005
Mus musculus (Q5MPP0), Mus musculus
brenda
Meixner, M.; Jungnickel, J.; Grothe, C.; Gieselmann, V.; Eckhardt, M.
Myelination in the absence of UDP-galactose: Ceramide galactosyl-transferase and fatty acid 2-hydroxylase
BMC Neurosci.
12
22
2011
Mus musculus (Q5MPP0)
brenda
Herrero, A.B.; Astudillo, A.M.; Balboa, M.A.; Cuevas, C.; Balsinde, J.; Moreno, S.
Levels of SCS7/FA2H-mediated fatty acid 2-hydroxylation determine the sensitivity of cells to antitumor PM02734
Cancer Res.
68
9779-9787
2008
Saccharomyces cerevisiae (Q03529), Saccharomyces cerevisiae, Homo sapiens (Q7L5A8), Homo sapiens
brenda
Hama, H.; Young, D.A.; Radding, J.A.; Ma, D.; Tang, J.; Stock, S.D.; Takemoto, J.Y.
Requirement of sphingolipid alpha-hydroxylation for fungicidal action of syringomycin E
FEBS Lett.
478
26-28
2000
Saccharomyces cerevisiae
brenda
Mitchell, A.; Martin, C.
Fah1p, a Saccharomyces cerevisiae cytochrome b5 fusion protein, and its Arabidopsis thaliana homolog that lacks the cytochrome b5 domain both function in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids
J. Biol. Chem.
272
28281-28288
1997
Saccharomyces cerevisiae (Q03529)
brenda
Alderson, N.; Rembiesa, B.; Walla, M.; Bielawska, A.; Bielawski, J.; Hama, H.
The human FA2H gene encodes a fatty acid 2-hydroxylase
J. Biol. Chem.
279
48562-48568
2004
Homo sapiens (Q7L5A8), Homo sapiens
brenda
Uchida, Y.; Hama, H.; Alderson, N.L.; Douangpanya, S.; Wang, Y.; Crumrine, D.A.; Elias, P.M.; Holleran, W.M.
Fatty acid 2-hydroxylase, encoded by FA2H, accounts for differentiation-associated increase in 2-OH ceramides during keratinocyte differentiation
J. Biol. Chem.
282
13211-13219
2007
Homo sapiens (Q7L5A8), Homo sapiens
brenda
Alderson, N.L.; Hama, H.
Fatty acid 2-hydroxylase regulates cAMP-induced cell cycle exit in D6P2T Schwannoma cells
J. Lipid Res.
50
1203-1208
2009
Rattus norvegicus
brenda
Guo, L.; Zhang, X.; Zhou, D.; Okunade, A.; Su, X.
Stereospecificity of fatty acid 2-hydroxylase and differential functions of 2-hydroxy fatty acid enantiomers
J. Lipid Res.
53
1327-1335
2012
Mus musculus (Q5MPP0), Homo sapiens (Q7L5A8), Homo sapiens
brenda
Dan, P.; Edvardson, S.; Bielawski, J.; Hama, H.; Saada, A.
2-hydroxylated sphingomyelin profiles in cells from patients with mutated fatty acid 2-hydroxylase
Lipids Health Dis.
10
84
2011
Homo sapiens
brenda
Tani, M.; Kuge, O.
Requirement of a specific group of sphingolipid-metabolizing enzyme for growth of yeast Saccharomyces cerevisiae under impaired metabolism of glycerophospholipids
Mol. Microbiol.
78
395-413
2010
Saccharomyces cerevisiae
brenda
Dunn, T.M.; Haak, D.; Monaghan, E.; Beeler, T.J.
Synthesis of monohydroxylated inositolphosphorylceramide (IPC-C) in Saccharomyces cerevisiae requires Scs7p, a protein with both a cytochrome b5-like domain and a hydroxylase/desaturase domain
Yeast
14
311-321
1998
Saccharomyces cerevisiae (Q03529), Saccharomyces cerevisiae
brenda
Li, R.; Xin, S.; Tao, C.; Jin, X.; Li, H.
Cotton ascorbate oxidase promotes cell growth in cultured tobacco bright Yellow-2 cells through generation of apoplast oxidation
Int. J. Mol. Sci.
18
1346
2017
Mus musculus
brenda
Zhu, G.; Koszelak-Rosenblum, M.; Connelly, S.M.; Dumont, M.E.; Malkowski, M.G.
The crystal structure of an integral membrane fatty acid alpha-hydroxylase
J. Biol. Chem.
290
29820-29833
2015
Saccharomyces cerevisiae (Q03529), Saccharomyces cerevisiae
brenda
Takeda, S.; Ikeda, E.; Su, S.; Harada, M.; Okazaki, H.; Yoshioka, Y.; Nishimura, H.; Ishii, H.; Kakizoe, K.; Taniguchi, A.; Tokuyasu, M.; Himeno, T.; Watanabe, K.; Omiecinski, C.J.; Aramaki, H.
DELTA9-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression possible involvement of induced levels of PPARalpha in MDA-MB-231 breast cancer cells
Toxicology
326
18-24
2014
Homo sapiens
brenda
Herzfeld, E.; Speh, L.; Strauss, C.; Scheller, C.
Nimodipine but not nifedipine promotes expression of fatty acid 2-hydroxylase in a surgical stress model based on neuro2a cells
Int. J. Mol. Sci.
18
E964
2017
Mus musculus (Q5MPP0)
brenda
Nagano, M.; Ishikawa, T.; Ogawa, Y.; Iwabuchi, M.; Nakasone, A.; Shimamoto, K.; Uchimiya, H.; Kawai-Yamada, M.
Arabidopsis Bax inhibitor-1 promotes sphingolipid synthesis during cold stress by interacting with ceramide-modifying enzymes
Planta
240
77-89
2014
Saccharomyces cerevisiae
brenda