Disease on EC 1.1.1.88 - hydroxymethylglutaryl-CoA reductase
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Acute Lung Injury
A Randomized Clinical Trial of Hydroxymethylglutaryl-CoA reductase Inhibition for Acute Lung Injury (The HARP study).
Acute Lung Injury
Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in Acute lung injury to Reduce Pulmonary dysfunction (HARP-2) trial: study protocol for a randomized controlled trial.
Alzheimer Disease
Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease.
Alzheimer Disease
Statins reduce amyloid-beta production through inhibition of protein isoprenylation.
Angina Pectoris
Cholesterol reduction yields clinical benefits: meta-analysis including recent trials.
Aortic Valve Stenosis
Effect of hydroxymethylglutaryl coenzyme a reductase inhibitors on the progression of calcific aortic stenosis.
Arthritis, Rheumatoid
Inhibition of protein geranylgeranylation induces apoptosis in synovial fibroblasts.
Atherosclerosis
Comparison of the effects of atorvastatin versus simvastatin on subclinical atherosclerosis in primary preventionas determined by electronbeam tomography.
Atherosclerosis
Effect of statin therapy before Q-wave myocardial infarction on myocardial perfusion.
Atherosclerosis
Geranylgeraniol prevents the cytotoxic effects of mevastatin in THP-1 cells, without decreasing the beneficial effects on cholesterol synthesis.
Atherosclerosis
Hydroxymethylglutaryl coenzyme A reductase inhibitors modify the inflammatory response of human macrophages and endothelial cells infected with Chlamydia pneumoniae.
Atherosclerosis
Inhibitory effect of co-administration of atorvastatin and endothelin-1 receptor antagonist on the progression of atherosclerosis in rabbit.
Breast Neoplasms
Molecular pathology of breast apocrine carcinomas: a protein expression signature specific for benign apocrine metaplasia.
Carcinogenesis
HMGCR is necessary for the tumorigenecity of esophageal squamous cell carcinoma and is regulated by Myc.
Carcinogenesis
Inhibitory effects of beta-carotene and vitamin a during the progression phase of hepatocarcinogenesis involve inhibition of cell proliferation but not alterations in DNA methylation.
Carcinoma
3-Hydroxy-3-methylglutaryl coenzyme A reductase activity and low-density lipoprotein receptor expression in diffuse-type and intestinal-type human gastric cancer.
Carcinoma, Hepatocellular
Loss of feedback control of hydroxymethylglutaryl coenzyme A reductase in hepatomas.
Carcinoma, Hepatocellular
Treatment of HCC with pravastatin, octreotide, or gemcitabine--a critical evaluation.
Cardiomegaly
Hydroxymethylglutaryl coenzyme A reductase inhibitor simvastatin prevents cardiac hypertrophy induced by pressure overload and inhibits p21ras activation.
Cardiomyopathy, Hypertrophic
HMG CoA reductase inhibition and left ventricular mass in hypertrophic cardiomyopathy: a randomized placebo-controlled pilot study.
Cardiovascular Diseases
Differences in susceptibility of HT-29 and A549 cells to statin-induced toxicity: An investigation using high content screening.
Cardiovascular Diseases
Do statins have a role in the prevention of age-related macular degeneration?
Cardiovascular Diseases
Hypertriglyceridemia: associated risks and effect of drug treatment.
Cardiovascular Diseases
Magnitude of HDL cholesterol variation after high-dose atorvastatin is genetically determined at the LDL receptor locus in patients with homozygous familial hypercholesterolemia.
Cardiovascular Diseases
Reversal of statin toxicity to human lymphocytes in tissue culture.
Cardiovascular Diseases
[THE EFFECTS OF STATINS IN SEPSIS AND ACUTE INFLAMMATORY RESPONSE].
Colorectal Neoplasms
Statin use is associated with a reduced incidence of colorectal adenomatous polyps.
Coronary Artery Disease
Hydroxymethylglutaryl coenzyme a reductase inhibitors down-regulate chemokines and chemokine receptors in patients with coronary artery disease.
Coronary Artery Disease
The efficacy and six-week tolerability of simvastatin 80 and 160 mg/day.
Coronary Disease
Cholesterol reduction yields clinical benefits: meta-analysis including recent trials.
Coronary Disease
Effects of a global risk educational tool on primary coronary prevention: the Atherosclerosis Assessment Via Total Risk (AVIATOR) study.
Coronary Disease
Pravastatin has cholesterol-lowering independent effects on the artery wall of atherosclerotic monkeys.
Coronary Disease
Rationale and design of a secondary prevention trial of lowering normal plasma cholesterol levels after acute myocardial infarction: the Cholesterol and Recurrent Events trial (CARE)
Coronary Disease
Therapy with hydroxymethylglutaryl coenzyme a reductase inhibitors (statins) and associated risk of incident cardiovascular events in older adults: evidence from the Cardiovascular Health Study.
Delirium
Evaluating early administration of the hydroxymethylglutaryl-CoA reductase inhibitor simvastatin in the prevention and treatment of delirium in critically ill ventilated patients (MoDUS trial): study protocol for a randomized controlled trial.
Dementia
The impact of the use of statins on the prevalence of dementia and the progression of cognitive impairment.
Demyelinating Diseases
Cerebroside synthesis as a measure of the rate of remyelination following cuprizone-induced demyelination in brain.
Diabetes Mellitus
Angiotensin-converting enzyme insertion/deletion polymorphism does not influence the restenosis rate after coronary stent implantation.
Diabetes Mellitus, Type 2
Effect of treatment with a hydroxymethylglutaryl coenzyme A reductase inhibitor on fasting and postprandial plasma lipoproteins and cholesteryl ester transfer activity in patients with NIDDM.
Diabetes Mellitus, Type 2
Evidence for metabolic aberrations in asymptomatic persons with type 2 diabetes after initiation of simvastatin therapy.
Diabetes Mellitus, Type 2
Hepatotoxicity associated with metformin therapy in treatment of type 2 diabetes mellitus with nonalcoholic fatty liver disease.
Diabetic Nephropathies
Antiproliferative effect of fluvastatin and thiazolidinedione in mesangial cells of diabetic rats.
Diabetic Retinopathy
Association of statin use with the risk of developing diabetic retinopathy.
Dyslipidemias
Effect of Hydroalcoholic Ginger Extract on Brain HMG-CoA Reductase and CYP46A1 Levels in Streptozotocin-induced Diabetic Rats.
Dyslipidemias
New insights into lipid metabolism in chronic kidney disease: what are the practical implications?
Dyslipidemias
[Dynamics of microrheologic properties of erythrocytes in patients with arterial hypertension and dyslipidemia treated with atorvastatin].
Dyslipidemias
[Treatment with hydroxymethylglutaryl coenzyme-A-reductase inhibitors in elderly patients: is it necessary?]
Encephalomyelitis
Expression profiles of cholesterol metabolism-related genes are altered during development of experimental autoimmune encephalomyelitis in the rat spinal cord.
Encephalomyelitis, Autoimmune, Experimental
Expression profiles of cholesterol metabolism-related genes are altered during development of experimental autoimmune encephalomyelitis in the rat spinal cord.
Gallstones
Effect of CS-514, a competitive inhibitor of hydroxymethylglutaryl coenzyme A reductase, on cholesterol gallstone formation in hamsters.
Gallstones
Inhibitory effects of pravastatin, a competitive inhibitor of hydroxymethylglutaryl coenzyme A reductase, on cholesterol gallstone formation in prairie dogs.
Gallstones
[Effects of a competitive inhibitor of hydroxymethylglutaryl coenzyme A reductase on cholesterol gallstone formation in prairie dogs]
Glioblastoma
EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy.
Glioma
Lipid metabolism impairment in human gliomas: expression of peroxisomal proteins in human gliomas at different grades of malignancy.
Heart Failure
Improvement of left ventricular remodeling and function by hydroxymethylglutaryl coenzyme a reductase inhibition with cerivastatin in rats with heart failure after myocardial infarction.
Heart Failure
Statin therapy is associated with improved survival in ischemic and non-ischemic heart failure.
Homozygous Familial Hypercholesterolemia
Magnitude of HDL cholesterol variation after high-dose atorvastatin is genetically determined at the LDL receptor locus in patients with homozygous familial hypercholesterolemia.
Homozygous Familial Hypercholesterolemia
Suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and of incorporation of acetate into cholesterol in homozygous hypercholesterolemic fibroblasts by ferritin-low density lipoprotein conjugates.
Hypercholesterolemia
Activity profile of gemfibrozil on the major plasma lipoprotein parameters.
Hypercholesterolemia
Cholesterol reduction yields clinical benefits: meta-analysis including recent trials.
Hypercholesterolemia
Effect of the HMG-CoA reductase inhibitors on blood pressure in patients with essential hypertension and primary hypercholesterolemia.
Hypercholesterolemia
Effects of simvastatin and pravastatin on hyperlipidemia and cyclosporin blood levels in renal transplant recipients.
Hypercholesterolemia
Elevated pregnancy-associated plasma protein-a in sera from type 2 diabetic patients with hypercholesterolemia: associations with carotid atherosclerosis and toe-brachial index.
Hypercholesterolemia
Hydroxymethylglutaryl coenzyme A reductase inhibitors as monotherapy in the treatment of hypercholesterolemia.
Hypercholesterolemia
Interactions between hypercholesterolemia and hypertension: implications for therapy.
Hypercholesterolemia
Pharmacological properties of marine macroalgae-associated heterotrophic bacteria.
Hypercholesterolemia
Synergistic interaction of lovastatin and paclitaxel in human cancer cells.
Hyperlipidemias
Effect of atorvastatin on cyclosporine pharmacokinetics in liver transplant recipients.
Hyperlipidemias
Effects of simvastatin and pravastatin on hyperlipidemia and cyclosporin blood levels in renal transplant recipients.
Hyperlipidemias
New insights into lipid metabolism in chronic kidney disease: what are the practical implications?
Hyperlipidemias
[Use of hydroxymethylglutaryl coenzyme A reductase inhibitors in patients with post-transplantation hyperlipemia]
Hyperlipoproteinemia Type II
Inhibition of exercise-induced shortening of bleeding time by fish oil in familial hypercholesterolemia (type IIa).
Hyperlipoproteinemia Type II
Serum lathosterol concentration is an indicator of whole-body cholesterol synthesis in humans.
Hyperlipoproteinemia Type II
The influence of mevinolin on the adrenal cortical response to corticotropin in heterozygous familial hypercholesterolemia.
Hypertension
Angiotensin-converting enzyme insertion/deletion polymorphism does not influence the restenosis rate after coronary stent implantation.
Hypertension
Effect of the HMG-CoA reductase inhibitors on blood pressure in patients with essential hypertension and primary hypercholesterolemia.
Hypertension
Pharmacological properties of marine macroalgae-associated heterotrophic bacteria.
Hypertension
[Dynamics of microrheologic properties of erythrocytes in patients with arterial hypertension and dyslipidemia treated with atorvastatin].
Hypertriglyceridemia
Effects of simvastatin and pravastatin on hyperlipidemia and cyclosporin blood levels in renal transplant recipients.
Infections
Antiviral activity of lovastatin against respiratory syncytial virus in vivo and in vitro.
Infections
Further investigations of race:cultivar-specific induction of enzymes related to phytoalexin biosynthesis in soybean roots following infection with Phytophthora megasperma f.sp. glycinea.
Insulin Resistance
Differential metabolic effects of rosuvastatin and pravastatin in hypercholesterolemic patients.
Kidney Failure, Chronic
Effect of Hydroxymethylglutaryl-CoA Reductase Inhibitors on Low-density Lipoprotein Cholesterol, Interleukin-6, and High-Sensitivity C-Reactive Protein in End-stage Renal Disease.
Leukemia
Lovastatin alters the isoprenoid biosynthetic pathway in acute myelogenous leukemia cells in vivo.
Leukemia, Myeloid
Inhibition of hydroxymethylglutaryl coenzyme A reductase activity induces a paradoxical increase in DNA synthesis in myeloid leukemia cells.
Muscular Diseases
Acute myopathy in a patient with concomitant use of pravastatin and colchicine.
Muscular Diseases
Potential drug interaction between simvastatin and danazol causing rhabdomyolysis.
Myocardial Infarction
Cholesterol reduction yields clinical benefits: meta-analysis including recent trials.
Myocardial Infarction
Effect of statins pretreatment on periprocedural myocardial infarction in patients undergoing percutaneous coronary intervention: a meta-analysis.
Myocardial Infarction
Hydroxymethylglutaryl-CoA reductase inhibitors in older persons with acute myocardial infarction: evidence for an age-statin interaction.
Myocardial Infarction
Impact of hydroxymethylglutaryl coenzyme a reductase inhibition on left ventricular remodeling after myocardial infarction: an experimental serial cardiac magnetic resonance imaging study.
Myocardial Infarction
Impact of hydroxymethylglutaryl coenzyme A reductase inhibition on left ventricular remodeling in patients with acute anterior myocardial infarction after primary coronary angioplasty.
Myocardial Infarction
Improvement of left ventricular remodeling and function by hydroxymethylglutaryl coenzyme a reductase inhibition with cerivastatin in rats with heart failure after myocardial infarction.
Myocardial Infarction
Rationale and design of a secondary prevention trial of lowering normal plasma cholesterol levels after acute myocardial infarction: the Cholesterol and Recurrent Events trial (CARE)
Myocardial Infarction
[Treatment with hydroxymethylglutaryl coenzyme-A-reductase inhibitors in elderly patients: is it necessary?]
Neoplasms
A discoordinate increase in the cellular amount of 3-hydroxy-3-methylglutaryl-CoA reductase results in the loss of rate-limiting control over cholesterogenesis in a tumour cell-free system.
Neoplasms
Biochemical effects, hypolipidemic and anti-inflammatory activities of Artemisia vulgaris extract in hypercholesterolemic rats.
Neoplasms
Effects of pravastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, on two human tumour cell lines.
Neoplasms
EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy.
Neoplasms
HMGCR is necessary for the tumorigenecity of esophageal squamous cell carcinoma and is regulated by Myc.
Neoplasms
Lipid composition and 3-hydroxy-3-methylglutaryl-CoA reductase activity of acinar cell carcinoma of rat pancreas.
Neoplasms
Lipid metabolism impairment in human gliomas: expression of peroxisomal proteins in human gliomas at different grades of malignancy.
Neoplasms
Pharmacodynamic effects of high dose lovastatin in subjects with advanced malignancies.
Neoplasms
Simvastatin enhances induction of inducible nitric oxide synthase in 3T3-L1 adipocytes.
Neoplasms
Sterol regulatory element-binding protein 1 inhibitors decrease pancreatic cancer cell viability and proliferation.
Nephrotic Syndrome
Should hyperlipidemia in children with the nephrotic syndrome be treated?
Pancreatic Neoplasms
Sterol regulatory element-binding protein 1 inhibitors decrease pancreatic cancer cell viability and proliferation.
Proteinuria
Effect of simvastatin on plasma lipid and lipoprotein concentrations and low-density lipoprotein metabolism in the nephrotic syndrome.
Renal Insufficiency
Associated effect of hepatic hydroxymethylglutaryl coenzyme A reductase + angiotensin converting enzyme inhibitors on the progression of renal failure in hypertensive subjects.
Respiratory Syncytial Virus Infections
Increased hydroxymethylglutaryl coenzyme A reductase activity during respiratory syncytial virus infection mediates actin dependent inter-cellular virus transmission.
Rhabdomyolysis
Overexpression of neural cell adhesion molecule in regenerative muscle fibers in 3-hydroxy-3-methylglutaryl coenzyme: A reductase inhibitor-induced rhabdomyolysis.
Rhabdomyolysis
Potential drug interaction between simvastatin and danazol causing rhabdomyolysis.
Sepsis
Hydroxymethylglutaryl-CoA reductase inhibitors (statins) for the treatment of sepsis in adults - A systematic review and meta-analysis.
Sepsis
Increased rates of hepatic cholesterogenesis and fatty acid synthesis in septic rats in vivo: evidence for the possible involvement of insulin.
Stomach Neoplasms
3-Hydroxy-3-methylglutaryl coenzyme A reductase activity and low-density lipoprotein receptor expression in diffuse-type and intestinal-type human gastric cancer.
Stroke
High-dose lovastatin for acute ischemic stroke: results of the phase I dose escalation neuroprotection with statin therapy for acute recovery trial (NeuSTART).
Stroke
[Treatment with hydroxymethylglutaryl coenzyme-A-reductase inhibitors in elderly patients: is it necessary?]
Subarachnoid Hemorrhage
Effect of prior statin use on functional outcome and delayed vasospasm after acute aneurysmal subarachnoid hemorrhage: a matched controlled cohort study.
Subarachnoid Hemorrhage
Statin treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage.
Ureteral Obstruction
Fluvastatin reduces renal fibroblast proliferation and production of type III collagen: therapeutic implications for tubulointerstitial fibrosis.
Vaccinia
Antiviral activity of lovastatin against respiratory syncytial virus in vivo and in vitro.
Vascular Calcification
Accelerated atherosclerotic calcification and Monckeberg's sclerosis: a continuum of advanced vascular pathology in chronic kidney disease.
Vascular Calcification
Amplification of atherosclerotic calcification and Mönckeberg's sclerosis: a spectrum of the same disease process.
Vascular System Injuries
Effects of hydroxymethylglutaryl coenzyme A reductase inhibitor simvastatin on smooth muscle cell proliferation in vitro and neointimal formation in vivo after vascular injury.
Vasospasm, Intracranial
Statin treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage.
Virus Diseases
Increased hydroxymethylglutaryl coenzyme A reductase activity during respiratory syncytial virus infection mediates actin dependent inter-cellular virus transmission.
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