1.14.13.22: cyclohexanone monooxygenase
This is an abbreviated version!
For detailed information about cyclohexanone monooxygenase, go to the full flat file.
Word Map on EC 1.14.13.22
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1.14.13.22
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baeyer-villiger
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acinetobacter
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lactones
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bvmos
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ncimb
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calcoaceticus
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cyclohexanol
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synthesis
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criegee
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epsilon-caprolactone
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c4a-peroxyflavin
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biooxidation
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bicyclo3.2.0hept-2-en-6-one
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phenylacetone
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cyclopentanone
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biotechnology
- 1.14.13.22
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baeyer-villiger
- acinetobacter
- lactones
-
bvmos
-
ncimb
- calcoaceticus
- cyclohexanol
- synthesis
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criegee
- epsilon-caprolactone
-
c4a-peroxyflavin
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biooxidation
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bicyclo3.2.0hept-2-en-6-one
- phenylacetone
- cyclopentanone
- biotechnology
Reaction
Synonyms
Bpro_556, CAMO, CHMO, ChnB, chnB protein, chnB1 protein, CHXON, CMO, cycloalkaone monooxygenase, cyclohexanone 1, 2-mono-oxygenase, cyclohexanone mono-oxygenase, cyclohexanone monooxygenase, cyclohexanone oxygenase, cyclohexanone:NADPH:oxygen oxidoreductase (lactone-forming), oxygenase, cyclohexanone mono-
ECTree
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General Information
General Information on EC 1.14.13.22 - cyclohexanone monooxygenase
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metabolism
flavoprotein that carries out the archetypical Baeyer-Villiger oxidation of a variety of cyclic ketones into lactones, size and shape of substrate binding pocket are adjustable to accommodate a diverse range of substrates
metabolism
residue T187 is critical for locking NADP+ in a configuration that dramatically accelerates O2 activation by the reduced flavin. W490 also promotes O2 activation (albeit less so than T187) and accelerates the reaction between the C4a-peroxyflavin and cyclohexanone
metabolism
wild type elicits a kinetic isotope effect of 4.7 and 1.1 with 4(R)-[4-2H]NADPH and 4(S)-[4-2H]NADPH, respectively, consistent with transfer of the proR hydrogen to FAD